PDB entry 1qr6

View 1qr6 on RCSB PDB site
Description: human mitochondrial nad(p)-dependent malic enzyme
Class: oxidoreductase
Keywords: four domains, rossmann fold, oxidoreductase
Deposited on 1999-06-18, released 1999-07-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.228
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: malic enzyme 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.08: d1qr6a1, d1qr6a2
  • Chain 'B':
    Compound: malic enzyme 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.08: d1qr6b1, d1qr6b2
  • Heterogens: NAD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1qr6A (A:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1qr6A (A:)
ekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtspleky
iyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdrgh
vrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclpvc
idvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnhna
frflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgianl
ivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfedavn
ilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegrcl
fasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakaltsql
tdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrsey
dsllpdvyewp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1qr6B (B:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1qr6B (B:)
ekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtspleky
iyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdrgh
vrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclpvc
idvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnhna
frflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgianl
ivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfedavn
ilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegrcl
fasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakaltsql
tdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrsey
dsllpdvyewp