PDB entry 1qki

View 1qki on RCSB PDB site
Description: x-ray structure of human glucose 6-phosphate dehydrogenase (variant canton r459l) complexed with structural nadp+
Class: oxidoreductase
Keywords: oxidoreductase, oxidoredutase, (choh(d)-nadp), glucose metabolism
Deposited on 1999-07-20, released 2000-03-16
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-06-16, with a file datestamp of 2009-06-12.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.247
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glucose-6-phosphate 1-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: G6PD
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11413
      • variant (457)
    Domains in SCOPe 2.05: d1qkia1, d1qkia2
  • Chain 'B':
    Compound: glucose-6-phosphate 1-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: G6PD
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11413
      • variant (457)
    Domains in SCOPe 2.05: d1qkib1, d1qkib2
  • Chain 'C':
    Compound: glucose-6-phosphate 1-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: G6PD
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11413
      • variant (457)
    Domains in SCOPe 2.05: d1qkic1, d1qkic2
  • Chain 'D':
    Compound: glucose-6-phosphate 1-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: G6PD
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11413
      • variant (457)
    Domains in SCOPe 2.05: d1qkid1, d1qkid2
  • Chain 'E':
    Compound: glucose-6-phosphate 1-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: G6PD
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11413
      • variant (457)
    Domains in SCOPe 2.05: d1qkie1, d1qkie2
  • Chain 'F':
    Compound: glucose-6-phosphate 1-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: G6PD
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11413
      • variant (457)
    Domains in SCOPe 2.05: d1qkif1, d1qkif2
  • Chain 'G':
    Compound: glucose-6-phosphate 1-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: G6PD
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11413
      • variant (457)
    Domains in SCOPe 2.05: d1qkig1, d1qkig2
  • Chain 'H':
    Compound: glucose-6-phosphate 1-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: G6PD
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11413
      • variant (457)
    Domains in SCOPe 2.05: d1qkih1, d1qkih2
  • Heterogens: NAP, GOA, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1qkiA (A:)
aeqvalsrthvcgilreelfqgdafhqsdthifiimgasgdlakkkiyptiwwlfrdgll
pentfivgyarsrltvadirkqsepffkatpeeklkledffarnsyvagqyddaasyqrl
nshmnalhlgsqanrlfylalpptvyeavtknihescmsqigwnriivekpfgrdlqssd
rlsnhisslfredqiyridhylgkemvqnlmvlrfanrifgpiwnrdniacviltfkepf
gtegrggyfdefgiirdvmqnhllqmlclvamekpastnsddvrdekvkvlkcisevqan
nvvlgqyvgnpdgegeatkgylddptvprgsttatfaavvlyvenerwdgvpfilrcgka
lnerkaevrlqfhdvagdifhqqckrnelvirvqpneavytkmmtkkpgmffnpeeseld
ltygnryknvklpdayerlildvfcgsqmhfvrsdelleawriftpllhqielekpkpip
yiygsrgpteadelmkrvgfqyegtykwvnphkl

    Sequence, based on observed residues (ATOM records): (download) 
    >1qkiA (A:)
vcghqsdthifiimgasgdlakkkiyptiwwlfrdgllpentfivgyarsrltvadirkq
sepffkatpeeklkledffarnsyvagqyddaasyqrlnshmnalhlgsqanrlfylalp
ptvyeavtknihescmsqigwnriivekpfgrdlqssdrlsnhisslfredqiyridhyl
gkemvqnlmvlrfanrifgpiwnrdniacviltfkepfgtegrggyfdefgiirdvmqnh
llqmlclvamekpastnsddvrdekvkvlkcisevqannvvlgqyvgnpdgegeatkgyl
ddptvprgsttatfaavvlyvenerwdgvpfilrcgkalnerkaevrlqfhdvagdifhq
qckrnelvirvqpneavytkmmtkkpgmffnpeeseldltygnryknvklpdayerlild
vfcgsqmhfvrsdelleawriftpllhqielekpkpipyiygsrgpteadelmkrvgfqy
egtykwvn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1qkiB (B:)
aeqvalsrthvcgilreelfqgdafhqsdthifiimgasgdlakkkiyptiwwlfrdgll
pentfivgyarsrltvadirkqsepffkatpeeklkledffarnsyvagqyddaasyqrl
nshmnalhlgsqanrlfylalpptvyeavtknihescmsqigwnriivekpfgrdlqssd
rlsnhisslfredqiyridhylgkemvqnlmvlrfanrifgpiwnrdniacviltfkepf
gtegrggyfdefgiirdvmqnhllqmlclvamekpastnsddvrdekvkvlkcisevqan
nvvlgqyvgnpdgegeatkgylddptvprgsttatfaavvlyvenerwdgvpfilrcgka
lnerkaevrlqfhdvagdifhqqckrnelvirvqpneavytkmmtkkpgmffnpeeseld
ltygnryknvklpdayerlildvfcgsqmhfvrsdelleawriftpllhqielekpkpip
yiygsrgpteadelmkrvgfqyegtykwvnphkl

    Sequence, based on observed residues (ATOM records): (download) 
    >1qkiB (B:)
hvcgiqsdthifiimgasgdlakkkiyptiwwlfrdgllpentfivgyarsrltvadirk
qsepffkatpeeklkledffarnsyvagqyddaasyqrlnshmnalhlgsqanrlfylal
pptvyeavtknihescmsqigwnriivekpfgrdlqssdrlsnhisslfredqiyridhy
lgkemvqnlmvlrfanrifgpiwnrdniacviltfkepfgtegrggyfdefgiirdvmqn
hllqmlclvamekpastnsddvrdekvkvlkcisevqannvvlgqyvgnpdgegeatkgy
lddptvprgsttatfaavvlyvenerwdgvpfilrcgkalnerkaevrlqfhdvagdifh
qqckrnelvirvqpneavytkmmtkkpgmffnpeeseldltygnryknvklpdayerlil
dvfcgsqmhfvrsdelleawriftpllhqielekpkpipyiygsrgpteadelmkrvgfq
yegtykwvn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1qkiC (C:)
aeqvalsrthvcgilreelfqgdafhqsdthifiimgasgdlakkkiyptiwwlfrdgll
pentfivgyarsrltvadirkqsepffkatpeeklkledffarnsyvagqyddaasyqrl
nshmnalhlgsqanrlfylalpptvyeavtknihescmsqigwnriivekpfgrdlqssd
rlsnhisslfredqiyridhylgkemvqnlmvlrfanrifgpiwnrdniacviltfkepf
gtegrggyfdefgiirdvmqnhllqmlclvamekpastnsddvrdekvkvlkcisevqan
nvvlgqyvgnpdgegeatkgylddptvprgsttatfaavvlyvenerwdgvpfilrcgka
lnerkaevrlqfhdvagdifhqqckrnelvirvqpneavytkmmtkkpgmffnpeeseld
ltygnryknvklpdayerlildvfcgsqmhfvrsdelleawriftpllhqielekpkpip
yiygsrgpteadelmkrvgfqyegtykwvnphkl

    Sequence, based on observed residues (ATOM records): (download) 
    >1qkiC (C:)
hvcgiqsdthifiimgasgdlakkkiyptiwwlfrdgllpentfivgyarsrltvadirk
qsepffkatpeeklkledffarnsyvagqyddaasyqrlnshmnalhlgsqanrlfylal
pptvyeavtknihescmsqigwnriivekpfgrdlqssdrlsnhisslfredqiyridhy
lgkemvqnlmvlrfanrifgpiwnrdniacviltfkepfgtegrggyfdefgiirdvmqn
hllqmlclvamekpastnsddvrdekvkvlkcisevqannvvlgqyvgnpdgegeatkgy
lddptvprgsttatfaavvlyvenerwdgvpfilrcgkalnerkaevrlqfhdvagdifh
qqckrnelvirvqpneavytkmmtkkpgmffnpeeseldltygnryknvklpdayerlil
dvfcgsqmhfvrsdelleawriftpllhqielekpkpipyiygsrgpteadelmkrvgfq
yegtykwvn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1qkiD (D:)
aeqvalsrthvcgilreelfqgdafhqsdthifiimgasgdlakkkiyptiwwlfrdgll
pentfivgyarsrltvadirkqsepffkatpeeklkledffarnsyvagqyddaasyqrl
nshmnalhlgsqanrlfylalpptvyeavtknihescmsqigwnriivekpfgrdlqssd
rlsnhisslfredqiyridhylgkemvqnlmvlrfanrifgpiwnrdniacviltfkepf
gtegrggyfdefgiirdvmqnhllqmlclvamekpastnsddvrdekvkvlkcisevqan
nvvlgqyvgnpdgegeatkgylddptvprgsttatfaavvlyvenerwdgvpfilrcgka
lnerkaevrlqfhdvagdifhqqckrnelvirvqpneavytkmmtkkpgmffnpeeseld
ltygnryknvklpdayerlildvfcgsqmhfvrsdelleawriftpllhqielekpkpip
yiygsrgpteadelmkrvgfqyegtykwvnphkl

    Sequence, based on observed residues (ATOM records): (download) 
    >1qkiD (D:)
thvcgiqsdthifiimgasgdlakkkiyptiwwlfrdgllpentfivgyarsrltvadir
kqsepffkatpeeklkledffarnsyvagqyddaasyqrlnshmnalhlgsqanrlfyla
lpptvyeavtknihescmsqigwnriivekpfgrdlqssdrlsnhisslfredqiyridh
ylgkemvqnlmvlrfanrifgpiwnrdniacviltfkepfgtegrggyfdefgiirdvmq
nhllqmlclvamekpastnsddvrdekvkvlkcisevqannvvlgqyvgnpdgegeatkg
ylddptvprgsttatfaavvlyvenerwdgvpfilrcgkalnerkaevrlqfhdvagdif
hqqckrnelvirvqpneavytkmmtkkpgmffnpeeseldltygnryknvklpdayerli
ldvfcgsqmhfvrsdelleawriftpllhqielekpkpipyiygsrgpteadelmkrvgf
qyegtykwvn

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1qkiE (E:)
aeqvalsrthvcgilreelfqgdafhqsdthifiimgasgdlakkkiyptiwwlfrdgll
pentfivgyarsrltvadirkqsepffkatpeeklkledffarnsyvagqyddaasyqrl
nshmnalhlgsqanrlfylalpptvyeavtknihescmsqigwnriivekpfgrdlqssd
rlsnhisslfredqiyridhylgkemvqnlmvlrfanrifgpiwnrdniacviltfkepf
gtegrggyfdefgiirdvmqnhllqmlclvamekpastnsddvrdekvkvlkcisevqan
nvvlgqyvgnpdgegeatkgylddptvprgsttatfaavvlyvenerwdgvpfilrcgka
lnerkaevrlqfhdvagdifhqqckrnelvirvqpneavytkmmtkkpgmffnpeeseld
ltygnryknvklpdayerlildvfcgsqmhfvrsdelleawriftpllhqielekpkpip
yiygsrgpteadelmkrvgfqyegtykwvnphkl

    Sequence, based on observed residues (ATOM records): (download) 
    >1qkiE (E:)
thvcsdthifiimgasgdlakkkiyptiwwlfrdgllpentfivgyarsrltvadirkqs
epffkatpeeklkledffarnsyvagqyddaasyqrlnshmnalhlgsqanrlfylalpp
tvyeavtknihescmsqigwnriivekpfgrdlqssdrlsnhisslfredqiyridhylg
kemvqnlmvlrfanrifgpiwnrdniacviltfkepfgtegrggyfdefgiirdvmqnhl
lqmlclvamekpastnsddvrdekvkvlkcisevqannvvlgqyvgnpdgegeatkgyld
dptvprgsttatfaavvlyvenerwdgvpfilrcgkalnerkaevrlqfhdvagdifhqq
ckrnelvirvqpneavytkmmtkkpgmffnpeeseldltygnryknvklpdayerlildv
fcgsqmhfvrsdelleawriftpllhqielekpkpipyiygsrgpteadelmkrvgfqye
gtykwvn

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1qkiF (F:)
aeqvalsrthvcgilreelfqgdafhqsdthifiimgasgdlakkkiyptiwwlfrdgll
pentfivgyarsrltvadirkqsepffkatpeeklkledffarnsyvagqyddaasyqrl
nshmnalhlgsqanrlfylalpptvyeavtknihescmsqigwnriivekpfgrdlqssd
rlsnhisslfredqiyridhylgkemvqnlmvlrfanrifgpiwnrdniacviltfkepf
gtegrggyfdefgiirdvmqnhllqmlclvamekpastnsddvrdekvkvlkcisevqan
nvvlgqyvgnpdgegeatkgylddptvprgsttatfaavvlyvenerwdgvpfilrcgka
lnerkaevrlqfhdvagdifhqqckrnelvirvqpneavytkmmtkkpgmffnpeeseld
ltygnryknvklpdayerlildvfcgsqmhfvrsdelleawriftpllhqielekpkpip
yiygsrgpteadelmkrvgfqyegtykwvnphkl

    Sequence, based on observed residues (ATOM records): (download) 
    >1qkiF (F:)
srthvcgqsdthifiimgasgdlakkkiyptiwwlfrdgllpentfivgyarsrltvadi
rkqsepffkatpeeklkledffarnsyvagqyddaasyqrlnshmnalhlgsqanrlfyl
alpptvyeavtknihescmsqigwnriivekpfgrdlqssdrlsnhisslfredqiyrid
hylgkemvqnlmvlrfanrifgpiwnrdniacviltfkepfgtegrggyfdefgiirdvm
qnhllqmlclvamekpastnsddvrdekvkvlkcisevqannvvlgqyvgnpdgegeatk
gylddptvprgsttatfaavvlyvenerwdgvpfilrcgkalnerkaevrlqfhdvagdi
fhqqckrnelvirvqpneavytkmmtkkpgmffnpeeseldltygnryknvklpdayerl
ildvfcgsqmhfvrsdelleawriftpllhqielekpkpipyiygsrgpteadelmkrvg
fqyegtykwvn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1qkiG (G:)
aeqvalsrthvcgilreelfqgdafhqsdthifiimgasgdlakkkiyptiwwlfrdgll
pentfivgyarsrltvadirkqsepffkatpeeklkledffarnsyvagqyddaasyqrl
nshmnalhlgsqanrlfylalpptvyeavtknihescmsqigwnriivekpfgrdlqssd
rlsnhisslfredqiyridhylgkemvqnlmvlrfanrifgpiwnrdniacviltfkepf
gtegrggyfdefgiirdvmqnhllqmlclvamekpastnsddvrdekvkvlkcisevqan
nvvlgqyvgnpdgegeatkgylddptvprgsttatfaavvlyvenerwdgvpfilrcgka
lnerkaevrlqfhdvagdifhqqckrnelvirvqpneavytkmmtkkpgmffnpeeseld
ltygnryknvklpdayerlildvfcgsqmhfvrsdelleawriftpllhqielekpkpip
yiygsrgpteadelmkrvgfqyegtykwvnphkl

    Sequence, based on observed residues (ATOM records): (download) 
    >1qkiG (G:)
thvcgqsdthifiimgasgdlakkkiyptiwwlfrdgllpentfivgyarsrltvadirk
qsepffkatpeeklkledffarnsyvagqyddaasyqrlnshmnalhlgsqanrlfylal
pptvyeavtknihescmsqigwnriivekpfgrdlqssdrlsnhisslfredqiyridhy
lgkemvqnlmvlrfanrifgpiwnrdniacviltfkepfgtegrggyfdefgiirdvmqn
hllqmlclvamekpastnsddvrdekvkvlkcisevqannvvlgqyvgnpdgegeatkgy
lddptvprgsttatfaavvlyvenerwdgvpfilrcgkalnerkaevrlqfhdvagdifh
qqckrnelvirvqpneavytkmmtkkpgmffnpeeseldltygnryknvklpdayerlil
dvfcgsqmhfvrsdelleawriftpllhqielekpkpipyiygsrgpteadelmkrvgfq
yegtykwvn

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1qkiH (H:)
aeqvalsrthvcgilreelfqgdafhqsdthifiimgasgdlakkkiyptiwwlfrdgll
pentfivgyarsrltvadirkqsepffkatpeeklkledffarnsyvagqyddaasyqrl
nshmnalhlgsqanrlfylalpptvyeavtknihescmsqigwnriivekpfgrdlqssd
rlsnhisslfredqiyridhylgkemvqnlmvlrfanrifgpiwnrdniacviltfkepf
gtegrggyfdefgiirdvmqnhllqmlclvamekpastnsddvrdekvkvlkcisevqan
nvvlgqyvgnpdgegeatkgylddptvprgsttatfaavvlyvenerwdgvpfilrcgka
lnerkaevrlqfhdvagdifhqqckrnelvirvqpneavytkmmtkkpgmffnpeeseld
ltygnryknvklpdayerlildvfcgsqmhfvrsdelleawriftpllhqielekpkpip
yiygsrgpteadelmkrvgfqyegtykwvnphkl

    Sequence, based on observed residues (ATOM records): (download) 
    >1qkiH (H:)
thvcgqsdthifiimgasgdlakkkiyptiwwlfrdgllpentfivgyarsrltvadirk
qsepffkatpeeklkledffarnsyvagqyddaasyqrlnshmnalhlgsqanrlfylal
pptvyeavtknihescmsqigwnriivekpfgrdlqssdrlsnhisslfredqiyridhy
lgkemvqnlmvlrfanrifgpiwnrdniacviltfkepfgtegrggyfdefgiirdvmqn
hllqmlclvamekpastnsddvrdekvkvlkcisevqannvvlgqyvgnpdgegeatkgy
lddptvprgsttatfaavvlyvenerwdgvpfilrcgkalnerkaevrlqfhdvagdifh
qqckrnelvirvqpneavytkmmtkkpgmffnpeeseldltygnryknvklpdayerlil
dvfcgsqmhfvrsdelleawriftpllhqielekpkpipyiygsrgpteadelmkrvgfq
yegtykwvn