PDB entry 1qhr

View 1qhr on RCSB PDB site
Description: novel covalent active site thrombin inhibitors
Class: blood clotting/hydrolase inhibitor
Keywords: proteinase, blood coagulation, trypsin like proteinase, complex (serine protease-inhibitor), blood clotting-hydrolase inhibitor complex
Deposited on 1999-05-26, released 2000-05-31
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.204
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: alpha thrombin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00734 (8-35)
  Domains in SCOPe 2.06: d1qhr.1
• Chain 'B':
  Compound: alpha thrombin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00734 (0-258)
  Domains in SCOPe 2.06: d1qhr.1
• Chain 'I':
  Compound: hirugen
  Species: Hirudo medicinalis, synthetic [TaxId:6421]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P28501 (0-9)
• Heterogens: 157, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1qhrA (A:)
  tfgsgeadcglrplfekksledkterellesyidgr
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1qhrB (B:)
  ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
  vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
  pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
  itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
  thvfrlkkwiqkvidqfge
  

  
  
• Chain 'I':
  No sequence available.