PDB entry 1qdu

View 1qdu on RCSB PDB site
Description: crystal structure of the complex of caspase-8 with the tripeptide ketone inhibitor zevd-dcbmk
Class: hydrolase/hydrolase inhibitor
Keywords: apoptosis, cysteine protease, hydrolase-hydrolase inhibitor complex
Deposited on 1999-07-10, released 2000-07-10
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.23
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: caspase-8 alpha-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14790 (0-152)
      • conflict (63)
    Domains in SCOPe 2.05: d1qdu.1
  • Chain 'B':
    Compound: caspase-8 beta-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1qdu.1
  • Chain 'C':
    Compound: caspase-8 alpha-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14790 (0-152)
      • conflict (63)
    Domains in SCOPe 2.05: d1qdu.2
  • Chain 'D':
    Compound: caspase-8 beta-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1qdu.2
  • Chain 'E':
    Compound: caspase-8 alpha-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14790 (0-152)
      • conflict (63)
    Domains in SCOPe 2.05: d1qdu.3
  • Chain 'F':
    Compound: caspase-8 beta-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1qdu.3
  • Chain 'G':
    Compound: caspase-8 alpha-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14790 (0-152)
      • conflict (63)
    Domains in SCOPe 2.05: d1qdu.4
  • Chain 'H':
    Compound: caspase-8 beta-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1qdu.4
  • Chain 'I':
    Compound: caspase-8 alpha-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14790 (0-152)
      • conflict (63)
    Domains in SCOPe 2.05: d1qdu.5
  • Chain 'J':
    Compound: caspase-8 beta-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1qdu.5
  • Chain 'K':
    Compound: caspase-8 alpha-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14790 (0-152)
      • conflict (63)
    Domains in SCOPe 2.05: d1qdu.6
  • Chain 'L':
    Compound: caspase-8 beta-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1qdu.6
  • Chain 'T':
    Compound: phq-glu-val-asp-dichloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1QDU
  • Chain 'U':
    Compound: phq-glu-val-asp-dichloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1QDU
  • Chain 'V':
    Compound: phq-glu-val-asp-dichloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1QDU
  • Chain 'W':
    Compound: phq-glu-val-asp-dichloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1QDU
  • Chain 'X':
    Compound: phq-glu-val-asp-dichloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1QDU
  • Chain 'Y':
    Compound: phq-glu-val-asp-dichloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1QDU (0-4)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1qduA (A:)
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetd

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1qduB (B:)
tryipdeadfllgmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnye
vsnkddkknmgkqmpqptftlrkklvfp

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1qduC (C:)
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetd

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1qduD (D:)
tryipdeadfllgmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnye
vsnkddkknmgkqmpqptftlrkklvfp

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1qduE (E:)
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetd

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1qduF (F:)
tryipdeadfllgmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnye
vsnkddkknmgkqmpqptftlrkklvfp

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1qduG (G:)
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetd

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1qduH (H:)
tryipdeadfllgmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnye
vsnkddkknmgkqmpqptftlrkklvfp

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1qduI (I:)
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetd

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1qduJ (J:)
tryipdeadfllgmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnye
vsnkddkknmgkqmpqptftlrkklvfp

  • Chain 'K':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1qduK (K:)
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetd

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1qduL (L:)
tryipdeadfllgmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnye
vsnkddkknmgkqmpqptftlrkklvfp

  • Chain 'T':
    No sequence available.

  • Chain 'U':
    No sequence available.

  • Chain 'V':
    No sequence available.

  • Chain 'W':
    No sequence available.

  • Chain 'X':
    No sequence available.

  • Chain 'Y':
    No sequence available.