PDB entry 1q4x

View 1q4x on RCSB PDB site
Description: Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific agonist GC-24
Class: transcription
Keywords: conformational change in two framework helices upon ligand binding, TRANSCRIPTION
Deposited on 2003-08-04, released 2004-02-03
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.216
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thyroid hormone receptor Beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: THRB OR NR1A2 OR ERBA2 OR THR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1q4xa_
  • Heterogens: G24, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1q4xA (A:)
ghkpeptdeeweliktvteahvatnaqgshwkqkrkflpedigqapivnapeggkvdlea
fshftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetl
tlngemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglac
veriekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecpt
elfpplflevfed

    Sequence, based on observed residues (ATOM records): (download) 
    >1q4xA (A:)
ghkpeptdeeweliktvteahvatnaqgshwkqkrkflpgkvdleafshftkiitpaitr
vvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetltlngemavtrgqlk
ngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglacveriekyqdsflla
fehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecptelfpplflevfed