PDB entry 1pvh
View 1pvh on RCSB PDB site
Description: Crystal structure of leukemia inhibitory factor in complex with gp130
Class: signaling protein/cytokine
Keywords: cytokine, receptor, signaling, beta sheet, four helix bundle, signaling protein/cytokine COMPLEX
Deposited on
2003-06-27, released
2003-10-14
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.248
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: interleukin-6 receptor beta chain
Species: Homo sapiens [TaxId:9606]
Gene: IL6ST
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1pvha1, d1pvha2 - Chain 'B':
Compound: leukemia inhibitory factor
Species: Homo sapiens [TaxId:9606]
Gene: LIF OR HILDA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1pvhb_ - Chain 'C':
Compound: interleukin-6 receptor beta chain
Species: Homo sapiens [TaxId:9606]
Gene: IL6ST
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1pvhc1, d1pvhc2 - Chain 'D':
Compound: leukemia inhibitory factor
Species: Homo sapiens [TaxId:9606]
Gene: LIF OR HILDA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1pvhd_ - Heterogens: IOD, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>1pvhA (A:)
glppekpknlscivnegkkmrcewdggrethletnftlksewathkfadckakrdtptsc
tvdystvyfvnievwveaenalgkvtsdhinfdpvykvkpnpphnlsvinseelssilkl
twtnpsiksviilkyniqyrtkdastwsqippedtastrssftvqdlkpfteyvfrircm
kedgkgywsdwseeasgitye
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1pvhB (B:)
cairhpchnnlmnqirsqlaqlngsanalfilyytaqgepfpnnldklcgpnvtdfppfh
angtekaklvelyrivvylgtslgnitrdqkilnpsalslhsklnatadilrgllsnvlc
rlcskyhvghvdvtygpdtsgkdvfqkkklgcqllgkykqiiavlaqaf
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>1pvhC (C:)
glppekpknlscivnegkkmrcewdggrethletnftlksewathkfadckakrdtptsc
tvdystvyfvnievwveaenalgkvtsdhinfdpvykvkpnpphnlsvinseelssilkl
twtnpsiksviilkyniqyrtkdastwsqippedtastrssftvqdlkpfteyvfrircm
kedgkgywsdwseeasgitye
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>1pvhD (D:)
cairhpchnnlmnqirsqlaqlngsanalfilyytaqgepfpnnldklcgpnvtdfppfh
angtekaklvelyrivvylgtslgnitrdqkilnpsalslhsklnatadilrgllsnvlc
rlcskyhvghvdvtygpdtsgkdvfqkkklgcqllgkykqiiavlaqaf