PDB entry 1pth

View 1pth on RCSB PDB site
Description: The Structural Basis of Aspirin Activity Inferred from the Crystal Structure of Inactivated Prostaglandin H2 Synthase
Class: oxidoreductase
Keywords: dioxygenase, peroxidase, oxidoreductase
Deposited on 1995-04-11, released 1996-04-11
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 3.4 Å
R-factor: 0.186
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: prostaglandin h2 synthase-1
    Species: Ovis aries [TaxId:9940]
    Database cross-references and differences (RAF-indexed):
    • PIR A29947
    Domains in SCOPe 2.01: d1ptha1, d1ptha2
  • Chain 'B':
    Compound: prostaglandin h2 synthase-1
    Species: Ovis aries [TaxId:9940]
    Database cross-references and differences (RAF-indexed):
    • PIR A29947
    Domains in SCOPe 2.01: d1pthb1, d1pthb2
  • Heterogens: NAG, BOG, HEM, SAL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1pthA (A:)
adpgapapvnpccyypcqhqgicvrfgldryqcdctrtgysgpnctipeiwtwlrttlrp
spsfihfllthgrwlwdfvnatfirdtlmrlvltvrsnlipspptyniahdyiswesfsn
vsyytrilpsvprdcptpmgtkgkkqlpdaeflsrrfllrrkfipdpqgtnlmfaffaqh
fthqffktsgkmgpgftkalghgvdlghiygdnlerqyqlrlfkdgklkyqmlngevypp
sveeapvlmhyprgippqsqmavgqevfgllpglmlyatiwlrehnrvcdllkaehptwg
deqlfqtarliligetikivieeyvqqlsgyflqlkfdpellfgaqfqyrnriamefnql
yhwhplmpdsfrvgpqdysyeqflfntsmlvdygvealvdafsrqpagrigggrnidhhi
lhvavdvikesrvlrlqpfneyrkrfgmkpytsfqeltgekemaaeleelygdidalefy
pglllekchpnsifgesmiemgapfslkgllgnpicspeywkastfggevgfnlvktatl
kklvclntktcpyvsfhvpdprqedrpgverpptel

    Sequence, based on observed residues (ATOM records): (download) 
    >1pthA (A:)
vnpccyypcqhqgicvrfgldryqcdctrtgysgpnctipeiwtwlrttlrpspsfihfl
lthgrwlwdfvnatfirdtlmrlvltvrsnlipspptyniahdyiswesfsnvsyytril
psvprdcptpmgtkgkkqlpdaeflsrrfllrrkfipdpqgtnlmfaffaqhfthqffkt
sgkmgpgftkalghgvdlghiygdnlerqyqlrlfkdgklkyqmlngevyppsveeapvl
mhyprgippqsqmavgqevfgllpglmlyatiwlrehnrvcdllkaehptwgdeqlfqta
rliligetikivieeyvqqlsgyflqlkfdpellfgaqfqyrnriamefnqlyhwhplmp
dsfrvgpqdysyeqflfntsmlvdygvealvdafsrqpagrigggrnidhhilhvavdvi
kesrvlrlqpfneyrkrfgmkpytsfqeltgekemaaeleelygdidalefypglllekc
hpnsifgesmiemgapfslkgllgnpicspeywkastfggevgfnlvktatlkklvclnt
ktcpyvsfhvp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1pthB (B:)
adpgapapvnpccyypcqhqgicvrfgldryqcdctrtgysgpnctipeiwtwlrttlrp
spsfihfllthgrwlwdfvnatfirdtlmrlvltvrsnlipspptyniahdyiswesfsn
vsyytrilpsvprdcptpmgtkgkkqlpdaeflsrrfllrrkfipdpqgtnlmfaffaqh
fthqffktsgkmgpgftkalghgvdlghiygdnlerqyqlrlfkdgklkyqmlngevypp
sveeapvlmhyprgippqsqmavgqevfgllpglmlyatiwlrehnrvcdllkaehptwg
deqlfqtarliligetikivieeyvqqlsgyflqlkfdpellfgaqfqyrnriamefnql
yhwhplmpdsfrvgpqdysyeqflfntsmlvdygvealvdafsrqpagrigggrnidhhi
lhvavdvikesrvlrlqpfneyrkrfgmkpytsfqeltgekemaaeleelygdidalefy
pglllekchpnsifgesmiemgapfslkgllgnpicspeywkastfggevgfnlvktatl
kklvclntktcpyvsfhvpdprqedrpgverpptel

    Sequence, based on observed residues (ATOM records): (download) 
    >1pthB (B:)
vnpccyypcqhqgicvrfgldryqcdctrtgysgpnctipeiwtwlrttlrpspsfihfl
lthgrwlwdfvnatfirdtlmrlvltvrsnlipspptyniahdyiswesfsnvsyytril
psvprdcptpmgtkgkkqlpdaeflsrrfllrrkfipdpqgtnlmfaffaqhfthqffkt
sgkmgpgftkalghgvdlghiygdnlerqyqlrlfkdgklkyqmlngevyppsveeapvl
mhyprgippqsqmavgqevfgllpglmlyatiwlrehnrvcdllkaehptwgdeqlfqta
rliligetikivieeyvqqlsgyflqlkfdpellfgaqfqyrnriamefnqlyhwhplmp
dsfrvgpqdysyeqflfntsmlvdygvealvdafsrqpagrigggrnidhhilhvavdvi
kesrvlrlqpfneyrkrfgmkpytsfqeltgekemaaeleelygdidalefypglllekc
hpnsifgesmiemgapfslkgllgnpicspeywkastfggevgfnlvktatlkklvclnt
ktcpyvsfhvp