PDB entry 1pn4

View 1pn4 on RCSB PDB site
Description: Crystal structure of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis multifunctional enzyme type 2 complexed with (3R)-hydroxydecanoyl-CoA.
Class: lyase
Keywords: Hot-Dog fold, Hydratase 2 motif, Oxyanion hole, Enzyme-product complex, LYASE
Deposited on 2003-06-12, released 2004-04-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-24, with a file datestamp of 2019-07-19.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peroxisomal hydratase-dehydrogenase-epimerase
    Species: Candida tropicalis [TaxId:5482]
    Gene: FOX2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22414
      • engineered (186)
    Domains in SCOPe 2.08: d1pn4a1, d1pn4a2
  • Chain 'B':
    Compound: Peroxisomal hydratase-dehydrogenase-epimerase
    Species: Candida tropicalis [TaxId:5482]
    Gene: FOX2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22414
      • engineered (186)
    Domains in SCOPe 2.08: d1pn4b1, d1pn4b2
  • Chain 'C':
    Compound: Peroxisomal hydratase-dehydrogenase-epimerase
    Species: Candida tropicalis [TaxId:5482]
    Gene: FOX2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22414
      • engineered (186)
    Domains in SCOPe 2.08: d1pn4c1, d1pn4c2
  • Chain 'D':
    Compound: Peroxisomal hydratase-dehydrogenase-epimerase
    Species: Candida tropicalis [TaxId:5482]
    Gene: FOX2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22414
      • engineered (186)
    Domains in SCOPe 2.08: d1pn4d1, d1pn4d2
  • Heterogens: HDC, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1pn4A (A:)
meddpvwrfddrdvilynialgattkqlkyvyendsdfqviptfghlitfnsgksqnsfa
kllrnfnpmlllhgehylkvhswppptegeikttfepiattpkgtnvvivhgsksvdnks
geliysneatyfirncqadnkvyadrpafatnqflapkrapdyqvdvpvsedlaalyrls
gdrnplqidpnfakgakfpkpilhgmctyglsakalidkfgmfneikarftgivfpgetl
rvlawkesddtivfqthvvdrgtiainnaaiklvgdkaki

    Sequence, based on observed residues (ATOM records): (download) 
    >1pn4A (A:)
pvwrfddrdvilynialgattkqlkyvyendsdfqviptfghlitfnsgksqnsfakllr
nfnpmlllhgehylkvhswppptegeikttfepiattpkgtnvvivhgsksvdnksgeli
ysneatyfirncqadnkvyadrpafatnqflapkrapdyqvdvpvsedlaalyrlsgdrn
plqidpnfakgakfpkpilhgmctyglsakalidkfgmfneikarftgivfpgetlrvla
wkesddtivfqthvvdrgtiainnaaiklvgd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1pn4B (B:)
meddpvwrfddrdvilynialgattkqlkyvyendsdfqviptfghlitfnsgksqnsfa
kllrnfnpmlllhgehylkvhswppptegeikttfepiattpkgtnvvivhgsksvdnks
geliysneatyfirncqadnkvyadrpafatnqflapkrapdyqvdvpvsedlaalyrls
gdrnplqidpnfakgakfpkpilhgmctyglsakalidkfgmfneikarftgivfpgetl
rvlawkesddtivfqthvvdrgtiainnaaiklvgdkaki

    Sequence, based on observed residues (ATOM records): (download) 
    >1pn4B (B:)
pvwrfddrdvilynialgattkqlkyvyendsdfqviptfghlitfnsgksqnsfakllr
nfnpmlllhgehylkvhswppptegeikttfepiattpkgtnvvivhgsksvdnksgeli
ysneatyfirncqadnkvyadrpafatnqflapkrapdyqvdvpvsedlaalyrlsgdrn
plqidpnfakgakfpkpilhgmctyglsakalidkfgmfneikarftgivfpgetlrvla
wkesddtivfqthvvdrgtiainnaaiklvgd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1pn4C (C:)
meddpvwrfddrdvilynialgattkqlkyvyendsdfqviptfghlitfnsgksqnsfa
kllrnfnpmlllhgehylkvhswppptegeikttfepiattpkgtnvvivhgsksvdnks
geliysneatyfirncqadnkvyadrpafatnqflapkrapdyqvdvpvsedlaalyrls
gdrnplqidpnfakgakfpkpilhgmctyglsakalidkfgmfneikarftgivfpgetl
rvlawkesddtivfqthvvdrgtiainnaaiklvgdkaki

    Sequence, based on observed residues (ATOM records): (download) 
    >1pn4C (C:)
dpvwrfddrdvilynialgattkqlkyvyendsdfqviptfghlitfnlhgehylkvhsw
ppptegeikttfepiattpvvivhgsksvdnksgeliysneatyfirncqadnkvyadrp
afatnqflapkrapdyqvdvpvsedlaalyrlsgdrnplqidpnfakgakfpkpilhgmc
tyglsakalidkfgmfneikarftgivfpgetlrvlawkesddtivfqthvvdrgtiain
naaiklv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1pn4D (D:)
meddpvwrfddrdvilynialgattkqlkyvyendsdfqviptfghlitfnsgksqnsfa
kllrnfnpmlllhgehylkvhswppptegeikttfepiattpkgtnvvivhgsksvdnks
geliysneatyfirncqadnkvyadrpafatnqflapkrapdyqvdvpvsedlaalyrls
gdrnplqidpnfakgakfpkpilhgmctyglsakalidkfgmfneikarftgivfpgetl
rvlawkesddtivfqthvvdrgtiainnaaiklvgdkaki

    Sequence, based on observed residues (ATOM records): (download) 
    >1pn4D (D:)
dpvwrfddrdvilynialgattkqlkyvyendsdfqviptfghlitfnsgksqnsfakll
rnfnpmlllhgehylkvhswppptegeikttfepiattpkgtnvvivhgsksvdnksgel
iysneatyfirncqadnkvyadrpafatnqflapkrapdyqvdvpvsedlaalyrlsgdr
nplqidpnfakgakfpkpilhgmctyglsakalidkfgmfneikarftgivfpgetlrvl
awkesddtivfqthvvdrgtiainnaaiklvgd