PDB entry 1pd8

View 1pd8 on RCSB PDB site
Description: Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase
Class: oxidoreductase
Keywords: human dihydrofolate reductase inhibitor complex, OXIDOREDUCTASE
Deposited on 2003-05-19, released 2003-12-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.197
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: dihydrofolate reductase
  Species: Homo sapiens [TaxId:9606]
  Gene: Dhfr
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00374 (0-185)
  Domains in SCOPe 2.07: d1pd8a_
• Heterogens: NDP, CO4, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1pd8A (A:)
  vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
  peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
  ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
  vyeknd