PDB entry 1p0p

View 1p0p on RCSB PDB site
Description: Crystal structure of soman-aged human butyryl cholinesterase in complex with the substrate analog butyrylthiocholine
Class: hydrolase
Keywords: Serine hydrolase, organophosphates, soman, butyrylthiocholine, cholinesterase, HYDROLASE
Deposited on 2003-04-10, released 2003-08-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: BCHE OR CHE1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06276 (Start-528)
      • engineered (16)
      • engineered (480)
      • engineered (485)
    Domains in SCOPe 2.08: d1p0pa_
  • Heterogens: NAG, SO4, CL, VXA, BCH, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1p0pA (A:)
eddiiiatkngkvrgmqltvfggtvtaflgipyaqpplgrlrfkkpqsltkwsdiwnatk
yansccqnidqsfpgfhgsemwnpntdlsedclylnvwipapkpknatvliwiygggfqt
gtsslhvydgkflarvervivvsmnyrvgalgflalpgnpeapgnmglfdqqlalqwvqk
niaafggnpksvtlfgesagaasvslhllspgshslftrailqsgsfnapwavtslyear
nrtlnlakltgcsreneteiikclrnkdpqeillneafvvpygtplsvnfgptvdgdflt
dmpdillelgqfkktqilvgvnkdegtaflvygapgfskdnnsiitrkefqeglkiffpg
vsefgkesilfhytdwvddqrpenyrealgdvvgdynficpaleftkkfsewgnnaffyy
fehrssklpwpewmgvmhgyeiefvfglplerrdqytkaeeilsrsivkrwanfakygnp
qetqnqstswpvfksteqkyltlntestrimtklraqqcrfwtsffpkv

    Sequence, based on observed residues (ATOM records): (download) 
    >1p0pA (A:)
iiiatkngkvrgmqltvfggtvtaflgipyaqpplgrlrfkkpqsltkwsdiwnatkyan
sccqnidqsfpgfhgsemwnpntdlsedclylnvwipapkpknatvliwiygggfqtgts
slhvydgkflarvervivvsmnyrvgalgflalpgnpeapgnmglfdqqlalqwvqknia
afggnpksvtlfgesagaasvslhllspgshslftrailqsgsfnapwavtslyearnrt
lnlakltgcsrneteiikclrnkdpqeillneafvvpygtplsvnfgptvdgdfltdmpd
illelgqfkktqilvgvnkdegtaflvygapgfskdnnsiitrkefqeglkiffpgvsef
gkesilfhytdwvqrpenyrealgdvvgdynficpaleftkkfsewgnnaffyyfehrss
klpwpewmgvmhgyeiefvfglplerrdytkaeeilsrsivkrwanfakygnpqetqnqs
tswpvfksteqkyltlntestrimtklraqqcrfwtsffpkv