PDB entry 1os9

View 1os9 on RCSB PDB site
Description: Binary enzyme-product complexes of human MMP12
Class: hydrolase
Keywords: matrix metalloproteinase, hydroxamic acid, mmp12, elastase, complex (elastase/inhibitor), metallo elastase
Deposited on 2003-03-19, released 2003-08-05
The last revision prior to the SCOP 1.75 freeze date was dated 2004-02-10, with a file datestamp of 2007-07-20.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.198
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Macrophage metalloelastase
    Species: HOMO SAPIENS
    Gene: MMP12 OR HME
    Database cross-references and differences (RAF-indexed):
    • Uniprot P39900 (2-164)
      • cloning artifact (0-1)
      • engineered (67)
    Domains in SCOP 1.75: d1os9a_
  • Chain 'B':
    Compound: Macrophage metalloelastase
    Species: HOMO SAPIENS
    Gene: MMP12 OR HME
    Database cross-references and differences (RAF-indexed):
    • Uniprot P39900 (2-164)
      • cloning artifact (0-1)
      • engineered (67)
    Domains in SCOP 1.75: d1os9b_
  • Chain 'C':
    Compound: Macrophage metalloelastase
    Species: HOMO SAPIENS
    Gene: MMP12 OR HME
    Database cross-references and differences (RAF-indexed):
    • Uniprot P39900 (2-164)
      • cloning artifact (0-1)
      • engineered (67)
    Domains in SCOP 1.75: d1os9c_
  • Chain 'D':
    Compound: Macrophage metalloelastase
    Species: HOMO SAPIENS
    Gene: MMP12 OR HME
    Database cross-references and differences (RAF-indexed):
    • Uniprot P39900 (2-164)
      • cloning artifact (0-1)
      • engineered (67)
    Domains in SCOP 1.75: d1os9d_
  • Chain 'E':
    Compound: Macrophage metalloelastase
    Species: HOMO SAPIENS
    Gene: MMP12 OR HME
    Database cross-references and differences (RAF-indexed):
    • Uniprot P39900 (2-164)
      • cloning artifact (0-1)
      • engineered (67)
    Domains in SCOP 1.75: d1os9e_
  • Chain 'F':
    Compound: Macrophage metalloelastase
    Species: HOMO SAPIENS
    Gene: MMP12 OR HME
    Database cross-references and differences (RAF-indexed):
    • Uniprot P39900 (2-164)
      • cloning artifact (0-1)
      • engineered (67)
    Domains in SCOP 1.75: d1os9f_
  • Heterogens: ZN, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1os9A (A:)
mmgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvf
argahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighs
lglghssdpkavmfptykyvdintfrlsaddirgiqslygdpken

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1os9B (B:)
mmgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvf
argahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighs
lglghssdpkavmfptykyvdintfrlsaddirgiqslygdpken

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1os9C (C:)
mmgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvf
argahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighs
lglghssdpkavmfptykyvdintfrlsaddirgiqslygdpken

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1os9D (D:)
mmgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvf
argahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighs
lglghssdpkavmfptykyvdintfrlsaddirgiqslygdpken

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1os9E (E:)
mmgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvf
argahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighs
lglghssdpkavmfptykyvdintfrlsaddirgiqslygdpken

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1os9F (F:)
mmgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvf
argahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighs
lglghssdpkavmfptykyvdintfrlsaddirgiqslygdpken