PDB entry 1on3

View 1on3 on RCSB PDB site
Description: Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core (with methylmalonyl-coenzyme a and methylmalonic acid bound)
Class: transferase
Keywords: carboxyl transferase, crystal structure, domain duplication, multienzyme complex, transcarboxylase
Deposited on 2003-02-26, released 2003-05-20
The last revision prior to the SCOP 1.75 freeze date was dated 2003-05-20, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.168
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Methylmalonyl-CoA carboxyltransferase 12S subunit
    Species: Propionibacterium freudenreichii
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1on3a1, d1on3a2
  • Chain 'B':
    Compound: Methylmalonyl-CoA carboxyltransferase 12S subunit
    Species: Propionibacterium freudenreichii
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1on3b1, d1on3b2
  • Chain 'C':
    Compound: Methylmalonyl-CoA carboxyltransferase 12S subunit
    Species: Propionibacterium freudenreichii
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1on3c1, d1on3c2
  • Chain 'D':
    Compound: Methylmalonyl-CoA carboxyltransferase 12S subunit
    Species: Propionibacterium freudenreichii
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1on3d1, d1on3d2
  • Chain 'E':
    Compound: Methylmalonyl-CoA carboxyltransferase 12S subunit
    Species: Propionibacterium freudenreichii
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1on3e1, d1on3e2
  • Chain 'F':
    Compound: Methylmalonyl-CoA carboxyltransferase 12S subunit
    Species: Propionibacterium freudenreichii
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1on3f1, d1on3f2
  • Heterogens: CD, MCA, DXX, MPD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1on3A (A:)
aennnlklastmegrveqlaeqrqvieagggerrvekqhsqgkqtarerlnnlldphsfd
evgafrkhrttlfgmdkavvpadgvvtgrgtilgrpvhaasqdftvmggsagetqstkvv
etmeqalltgtpflffydsggariqegidslsgygkmffanvklsgvvpqiaiiagpcag
gasyspaltdfiimtkkahmfitgpqviksvtgedvtadelggaeahmaisgnihfvaed
ddaaeliakkllsflpqnnteeasfvnpnndvspntelrdivpidgkkgydvrdviakiv
dwgdylevkagyatnlvtafarvngrsvgivanqpsvmsgcldinasdkaaefvnfcdsf
niplvqlvdvpgflpgvqqeyggiirhgakmlyayseatvpkitvvlrkayggsylamcn
rdlgadavyawpsaeiavmgaegaanvifrkeikaaddpdamraekieeyqnafntpyva
aargqvddvidpadtrrkiasalemyatkrqtrpakkhgnfpc

    Sequence, based on observed residues (ATOM records): (download) 
    >1on3A (A:)
klastmegrveqlaeqrqvieagggerrvekqhsqgkqtarerlnnlldphsfdevgafr
khrttlfgmdkavvpadgvvtgrgtilgrpvhaasqdftvmggsagetqstkvvetmeqa
lltgtpflffydsggariqegidslsgygkmffanvklsgvvpqiaiiagpcaggasysp
altdfiimtkkahmfitgpqviksvtgedvtadelggaeahmaisgnihfvaedddaael
iakkllsflpqnnteeasfvnpnndvspntelrdivpidgkkgydvrdviakivdwgdyl
evkagyatnlvtafarvngrsvgivanqpsvmsgcldinasdkaaefvnfcdsfniplvq
lvdvpgflpgvqqeyggiirhgakmlyayseatvpkitvvlrkayggsylamcnrdlgad
avyawpsaeiavmgaegaanvifrkeikaaddpdamraekieeyqnafntpyvaaargqv
ddvidpadtrrkiasalemyatkrqtrpakkhgnfpc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1on3B (B:)
aennnlklastmegrveqlaeqrqvieagggerrvekqhsqgkqtarerlnnlldphsfd
evgafrkhrttlfgmdkavvpadgvvtgrgtilgrpvhaasqdftvmggsagetqstkvv
etmeqalltgtpflffydsggariqegidslsgygkmffanvklsgvvpqiaiiagpcag
gasyspaltdfiimtkkahmfitgpqviksvtgedvtadelggaeahmaisgnihfvaed
ddaaeliakkllsflpqnnteeasfvnpnndvspntelrdivpidgkkgydvrdviakiv
dwgdylevkagyatnlvtafarvngrsvgivanqpsvmsgcldinasdkaaefvnfcdsf
niplvqlvdvpgflpgvqqeyggiirhgakmlyayseatvpkitvvlrkayggsylamcn
rdlgadavyawpsaeiavmgaegaanvifrkeikaaddpdamraekieeyqnafntpyva
aargqvddvidpadtrrkiasalemyatkrqtrpakkhgnfpc

    Sequence, based on observed residues (ATOM records): (download) 
    >1on3B (B:)
lastmegrveqlaeqrqvieagggerrvekqhsqgkqtarerlnnlldphsfdevgafrk
hrttlfgmdkavvpadgvvtgrgtilgrpvhaasqdftvmggsagetqstkvvetmeqal
ltgtpflffydsggariqegidslsgygkmffanvklsgvvpqiaiiagpcaggasyspa
ltdfiimtkkahmfitgpqviksvtgedvtadelggaeahmaisgnihfvaedddaaeli
akkllsflpqnnteeasfvnpnndvspntelrdivpidgkkgydvrdviakivdwgdyle
vkagyatnlvtafarvngrsvgivanqpsvmsgcldinasdkaaefvnfcdsfniplvql
vdvpgflpgvqqeyggiirhgakmlyayseatvpkitvvlrkayggsylamcnrdlgada
vyawpsaeiavmgaegaanvifrkeikaaddpdamraekieeyqnafntpyvaaargqvd
dvidpadtrrkiasalemyatkrqtrpakkhgnfpc

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1on3C (C:)
aennnlklastmegrveqlaeqrqvieagggerrvekqhsqgkqtarerlnnlldphsfd
evgafrkhrttlfgmdkavvpadgvvtgrgtilgrpvhaasqdftvmggsagetqstkvv
etmeqalltgtpflffydsggariqegidslsgygkmffanvklsgvvpqiaiiagpcag
gasyspaltdfiimtkkahmfitgpqviksvtgedvtadelggaeahmaisgnihfvaed
ddaaeliakkllsflpqnnteeasfvnpnndvspntelrdivpidgkkgydvrdviakiv
dwgdylevkagyatnlvtafarvngrsvgivanqpsvmsgcldinasdkaaefvnfcdsf
niplvqlvdvpgflpgvqqeyggiirhgakmlyayseatvpkitvvlrkayggsylamcn
rdlgadavyawpsaeiavmgaegaanvifrkeikaaddpdamraekieeyqnafntpyva
aargqvddvidpadtrrkiasalemyatkrqtrpakkhgnfpc

    Sequence, based on observed residues (ATOM records): (download) 
    >1on3C (C:)
lastmegrveqlaeqrqvieagggerrvekqhsqgkqtarerlnnlldphsfdevgafrk
hrttlfgmdkavvpadgvvtgrgtilgrpvhaasqdftvmggsagetqstkvvetmeqal
ltgtpflffydsggariqegidslsgygkmffanvklsgvvpqiaiiagpcaggasyspa
ltdfiimtkkahmfitgpqviksvtgedvtadelggaeahmaisgnihfvaedddaaeli
akkllsflpqnnteeasfvnpnndvspntelrdivpidgkkgydvrdviakivdwgdyle
vkagyatnlvtafarvngrsvgivanqpsvmsgcldinasdkaaefvnfcdsfniplvql
vdvpgflpgvqqeyggiirhgakmlyayseatvpkitvvlrkayggsylamcnrdlgada
vyawpsaeiavmgaegaanvifrkepdamraekieeyqnafntpyvaaargqvddvidpa
dtrrkiasalemyatkrqtrpakkhgnfpc

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1on3D (D:)
aennnlklastmegrveqlaeqrqvieagggerrvekqhsqgkqtarerlnnlldphsfd
evgafrkhrttlfgmdkavvpadgvvtgrgtilgrpvhaasqdftvmggsagetqstkvv
etmeqalltgtpflffydsggariqegidslsgygkmffanvklsgvvpqiaiiagpcag
gasyspaltdfiimtkkahmfitgpqviksvtgedvtadelggaeahmaisgnihfvaed
ddaaeliakkllsflpqnnteeasfvnpnndvspntelrdivpidgkkgydvrdviakiv
dwgdylevkagyatnlvtafarvngrsvgivanqpsvmsgcldinasdkaaefvnfcdsf
niplvqlvdvpgflpgvqqeyggiirhgakmlyayseatvpkitvvlrkayggsylamcn
rdlgadavyawpsaeiavmgaegaanvifrkeikaaddpdamraekieeyqnafntpyva
aargqvddvidpadtrrkiasalemyatkrqtrpakkhgnfpc

    Sequence, based on observed residues (ATOM records): (download) 
    >1on3D (D:)
lklastmegrveqlaeqrqvieagggerrvekqhsqgkqtarerlnnlldphsfdevgaf
rkhrttlfgmdkavvpadgvvtgrgtilgrpvhaasqdftvmggsagetqstkvvetmeq
alltgtpflffydsggariqegidslsgygkmffanvklsgvvpqiaiiagpcaggasys
paltdfiimtkkahmfitgpqviksvtgedvtadelggaeahmaisgnihfvaedddaae
liakkllsflpqnnteeasfvnpnndvspntelrdivpidgkkgydvrdviakivdwgdy
levkagyatnlvtafarvngrsvgivanqpsvmsgcldinasdkaaefvnfcdsfniplv
qlvdvpgflpgvqqeyggiirhgakmlyayseatvpkitvvlrkayggsylamcnrdlga
davyawpsaeiavmgaegaanvifrkeikdamraekieeyqnafntpyvaaargqvddvi
dpadtrrkiasalemyatkrqtrpakkhgnfpc

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1on3E (E:)
aennnlklastmegrveqlaeqrqvieagggerrvekqhsqgkqtarerlnnlldphsfd
evgafrkhrttlfgmdkavvpadgvvtgrgtilgrpvhaasqdftvmggsagetqstkvv
etmeqalltgtpflffydsggariqegidslsgygkmffanvklsgvvpqiaiiagpcag
gasyspaltdfiimtkkahmfitgpqviksvtgedvtadelggaeahmaisgnihfvaed
ddaaeliakkllsflpqnnteeasfvnpnndvspntelrdivpidgkkgydvrdviakiv
dwgdylevkagyatnlvtafarvngrsvgivanqpsvmsgcldinasdkaaefvnfcdsf
niplvqlvdvpgflpgvqqeyggiirhgakmlyayseatvpkitvvlrkayggsylamcn
rdlgadavyawpsaeiavmgaegaanvifrkeikaaddpdamraekieeyqnafntpyva
aargqvddvidpadtrrkiasalemyatkrqtrpakkhgnfpc

    Sequence, based on observed residues (ATOM records): (download) 
    >1on3E (E:)
nnlklastmegrveqlaeqrqvieagggerrvekqhsqgkqtarerlnnlldphsfdevg
afrkhrttlfgmdkavvpadgvvtgrgtilgrpvhaasqdftvmggsagetqstkvvetm
eqalltgtpflffydsggariqegidslsgygkmffanvklsgvvpqiaiiagpcaggas
yspaltdfiimtkkahmfitgpqviksvtgedvtadelggaeahmaisgnihfvaeddda
aeliakkllsflpqnnteeasfvnpnndvspntelrdivpidgkkgydvrdviakivdwg
dylevkagyatnlvtafarvngrsvgivanqpsvmsgcldinasdkaaefvnfcdsfnip
lvqlvdvpgflpgvqqeyggiirhgakmlyayseatvpkitvvlrkayggsylamcnrdl
gadavyawpsaeiavmgaegaanvifrkeikaaddpdamraekieeyqnafntpyvaaar
gqvddvidpadtrrkiasalemyatkrqtrpakkhgnfpc

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1on3F (F:)
aennnlklastmegrveqlaeqrqvieagggerrvekqhsqgkqtarerlnnlldphsfd
evgafrkhrttlfgmdkavvpadgvvtgrgtilgrpvhaasqdftvmggsagetqstkvv
etmeqalltgtpflffydsggariqegidslsgygkmffanvklsgvvpqiaiiagpcag
gasyspaltdfiimtkkahmfitgpqviksvtgedvtadelggaeahmaisgnihfvaed
ddaaeliakkllsflpqnnteeasfvnpnndvspntelrdivpidgkkgydvrdviakiv
dwgdylevkagyatnlvtafarvngrsvgivanqpsvmsgcldinasdkaaefvnfcdsf
niplvqlvdvpgflpgvqqeyggiirhgakmlyayseatvpkitvvlrkayggsylamcn
rdlgadavyawpsaeiavmgaegaanvifrkeikaaddpdamraekieeyqnafntpyva
aargqvddvidpadtrrkiasalemyatkrqtrpakkhgnfpc

    Sequence, based on observed residues (ATOM records): (download) 
    >1on3F (F:)
klastmegrveqlaeqrqvieagggerrvekqhsqgkqtarerlnnlldphsfdevgafr
khrttlfgmdkavvpadgvvtgrgtilgrpvhaasqdftvmggsagetqstkvvetmeqa
lltgtpflffydsggariqegidslsgygkmffanvklsgvvpqiaiiagpcaggasysp
altdfiimtkkahmfitgpqviksvtgedvtadelggaeahmaisgnihfvaedddaael
iakkllsflpqnnteeasfvnpnndvspntelrdivpidgkkgydvrdviakivdwgdyl
evkagyatnlvtafarvngrsvgivanqpsvmsgcldinasdkaaefvnfcdsfniplvq
lvdvpgflpgvqqeyggiirhgakmlyayseatvpkitvvlrkayggsylamcnrdlgad
avyawpsaeiavmgaegaanvifrkeikaaddpdamraekieeyqnafntpyvaaargqv
ddvidpadtrrkiasalemyatkrqtrpakkhgnfpc