PDB entry 1ofr

View 1ofr on RCSB PDB site
Description: crystal structure of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae complexed with phenylalanine and manganese
Class: lyase
Keywords: beta-alpha-barrel, lyase, aromatic amino-acid biosynthesis
Deposited on 2003-04-18, released 2004-04-15
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-06-16, with a file datestamp of 2009-06-12.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.232
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1ofra_
  • Chain 'B':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1ofrb_
  • Chain 'C':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1ofrc_
  • Chain 'D':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1ofrd_
  • Chain 'E':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1ofre_
  • Chain 'F':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1ofrf_
  • Chain 'G':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1ofrg_
  • Chain 'H':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1ofrh_
  • Heterogens: PHE, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1ofrA (A:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1ofrA (A:)
eedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcsih
dleaaqeyalrlkklsdelkgdlsiimraylekprtvgwkglindpdvnntfninkglqs
arqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgf
kngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnydak
svaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesnin
egnqgipaegkaglkygvsitdacigwettedvlrklaaavrqrrevnkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1ofrB (B:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1ofrB (B:)
aeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcsi
hdleaaqeyalrlkklsdelkgdlsiimraylekprvgwkglindpdvnntfninkglqs
arqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgf
kngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkgtnydaks
vaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesnine
gnqgipaegkalkygvsitdacigwettedvlrklaaavrqrrevnkk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1ofrC (C:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1ofrC (C:)
eedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcsih
dleaaqeyalrlkklsdelkgdlsiimraylekprvgwkglindpdvnntfninkglqsa
rqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfk
ngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnydaks
vaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesnine
gnqgipaegkaglkygvsitdacigwettedvlrklaaavrqrrevnkk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1ofrD (D:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1ofrD (D:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylekprvgwkglindpdvnntfninkglq
sarqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvg
fkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnyda
ksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesni
negnqgipaegkaglkygvsitdacigwettedvlrklaaavrqrrevnkk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1ofrE (E:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1ofrE (E:)
eedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcsih
dleaaqeyalrlkklsdelkgdlsiimraylekpwkglindpdvnntfninkglqsarql
fvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfkngt
dgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnydaksvae
akaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesninegnq
gipkygvsitdacigwettedvlrklaaavrqrrevnkk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1ofrF (F:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1ofrF (F:)
eedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcsih
dleaaqeyalrlkklsdelkgdlsiimraylekprvgwkglindpdvnntfninkglqsa
rqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfk
ngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnydaks
vaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesnine
gnqgipgkaglkygvsitdacigwettedvlrklaaavrqrrevnkk

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1ofrG (G:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1ofrG (G:)
aeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcsi
hdleaaqeyalrlkklsdelkgdlsiimraylekpgwkglindpdvnntfninkglqsar
qlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfkn
gtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnydaksv
aeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesnineg
nqipaeaglkygvsitdacigwettedvlrklaaavrqrrevnk

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1ofrH (H:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1ofrH (H:)
eedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcsih
dleaaqeyalrlkklsdelkgdlsiimraylekprttvgwkglindpdvnntfninkglq
sarqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvg
fkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnyda
ksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesni
negnqgipaaglkygvsitdacigwettedvlrklaaavrqrrevnk