PDB entry 1of6

View 1of6 on RCSB PDB site
Description: crystal structure of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae complexed with tyrosine and manganese
Class: lyase
Keywords: beta-alpha-barrel, lyase, synthase, aldolase, synthetase
Deposited on 2003-04-08, released 2004-05-06
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-02-05, with a file datestamp of 2014-01-31.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.195
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1of6a_
  • Chain 'B':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1of6b_
  • Chain 'C':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1of6c_
  • Chain 'D':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1of6d_
  • Chain 'E':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1of6e_
  • Chain 'F':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1of6f_
  • Chain 'G':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1of6g_
  • Chain 'H':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1of6h_
  • Heterogens: MN, DTY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1of6A (A:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1of6A (A:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylekprtvgwkglindpdvnntfninkgl
qsarqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpv
gfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnyd
aksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesn
inegnqgipaegkaglkygvsitdacigwettedvlrklaaavrqrrevn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1of6B (B:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1of6B (B:)
aeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcsi
hdleaaqeyalrlkklsdelkgdlsiimraylekprvgwkglindpdvnntfninkglqs
arqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgf
kngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkgtnydaks
vaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesnine
gnqgipaegkalkygvsitdacigwettedvlrklaaavrqrrevn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1of6C (C:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1of6C (C:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylekprvgwkglindpdvnntfninkglq
sarqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvg
fkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnyda
ksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesni
negnqgipaegkaglkygvsitdacigwettedvlrklaaavrqrrevnk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1of6D (D:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1of6D (D:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylekprvgwkglindpdvnntfninkglq
sarqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvg
fkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnyda
ksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesni
negnqgipaegkaglkygvsitdacigwettedvlrklaaavrqrrevn

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1of6E (E:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1of6E (E:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylekpwkglindpdvnntfninkglqsar
qlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfkn
gtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnydaksv
aeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesnineg
nqgipkygvsitdacigwettedvlrklaaavrqrrevn

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1of6F (F:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1of6F (F:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylekprvgwkglindpdvnntfninkglq
sarqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvg
fkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnyda
ksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesni
negnqgipgkaglkygvsitdacigwettedvlrklaaavrqrrevn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1of6G (G:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1of6G (G:)
aeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcsi
hdleaaqeyalrlkklsdelkgdlsiimraylekpgwkglindpdvnntfninkglqsar
qlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfkn
gtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtnydaksv
aeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesnineg
nqipaeaglkygvsitdacigwettedvlrklaaavrqrrev

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1of6H (H:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1of6H (H:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwkglindpdvnntfninkg
lqsarqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfp
vgfkngtdgtlnvavdacqaaahshhfmgvtkhgvaaitttkgnehcfvilrggkkgtny
daksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmies
ninegnqgipaaglkygvsitdacigwettedvlrklaaavrqrrev