PDB entry 1o7d

View 1o7d on RCSB PDB site
Description: the structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low ph activation
Class: hydrolase
Keywords: hydrolase, glycosyl hydrolase family 38, a-mannosidase, lysosomal
Deposited on 2002-10-30, released 2003-03-20
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.257
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lysosomal alpha-mannosidase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q29451
      • conflict see remark 9 (125)
    Domains in SCOPe 2.02: d1o7d.3
  • Chain 'B':
    Compound: lysosomal alpha-mannosidase
    Species: Bos taurus [TaxId:9913]
    Domains in SCOPe 2.02: d1o7d.1, d1o7d.3
  • Chain 'C':
    Compound: lysosomal alpha-mannosidase
    Species: Bos taurus [TaxId:9913]
    Domains in SCOPe 2.02: d1o7d.1, d1o7d.2
  • Chain 'D':
    Compound: lysosomal alpha-mannosidase
    Species: Bos taurus [TaxId:9913]
    Domains in SCOPe 2.02: d1o7d.2
  • Chain 'E':
    Compound: lysosomal alpha-mannosidase
    Species: Bos taurus [TaxId:9913]
    Domains in SCOPe 2.02: d1o7d.2
  • Heterogens: NAG, TRS, ZN, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1o7dA (A:)
agyktcpkvkpdmlnvhlvphthddvgwlktvdqyfygiynniqpagvqyildsvissll
anptrrfiyveiaffsrwwrqqtnatqkivrelvrqgrlefanggwvmndeatthygaii
dqmtlglrfleetfgsdgrprvawhidpfghsreqaslfaqmgfdgfffgrldyqdkkvr
kktlqmeqvwrastslkpptadlftsvlpnmynppeglcwdmlcadkpvvedtrspeyna
kelvryflklatdqgklyrtkhtvmtmgsdfqyenantwfknldkliqlvnaqqrang

    Sequence, based on observed residues (ATOM records): (download) 
    >1o7dA (A:)
gyktcpkvkpdmlnvhlvphthddvgwlktvdqyfygiynniqpagvqyildsvisslla
nptrrfiyveiaffsrwwrqqtnatqkivrelvrqgrlefanggwvmndeatthygaiid
qmtlglrfleetfgsdgrprvawhidpfghsreqaslfaqmgfdgfffgrldyqdkkvrk
ktlqmeqvwrastslkpptadlftsvlpnmynppeglcwdmlcadkpvvedtrspeynak
elvryflklatdqgklyrtkhtvmtmgsdfqyenantwfknldkliqlvnaq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1o7dB (B:)
irvnvlystpacylwelnkanlswsvkkddffpyadgpymfwtgyfssrpalkryerlsy
nflqvcnqlealagpaanvgpygs

    Sequence, based on observed residues (ATOM records): (download) 
    >1o7dB (B:)
irvnvlystpacylwelnkanlswsvkkddffpyadgpymfwtgyfssrpalkryerlsy
nflqvcnqlealagpa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1o7dC (C:)
gdsaplneamavlqhhdavsgtsrqhvandyarqlsegwrpcevlmsnalahlsglkedf
afcrklnisicpltqtaerfqvivynplgrkvdwmvrlpvskhvylvkdpggkivpsdvv
tipssdsqellfsalvpavgfsiysvsqmpnqrpqksws

    Sequence, based on observed residues (ATOM records): (download) 
    >1o7dC (C:)
gdsaplneamavlqhhdavsgtsrqhvandyarqlsegwrpcevlmsnalahlsglkedf
afcrklnisicpltqtaerfqvivynplgrkvdwmvrlpvskhvylvkdpggkivpsdvv
tipssdsqellfsalvpavgfsiysvsqmpn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1o7dD (D:)
rdlviqneylrarfdpntgllmelenleqnlllpvrqafywynastgnnlssqasgayif
rpnqnkplfvshwaqthlvkaslvqevhqnfsawcsqvvrlyprqrhlelewtvgpipvg
dgwgkevisrfdtalatrglfytdsngreilerrrnyrptwklnqtepvagnyypvnsri
yitdgnmqltvltdrsqggsslrdgslelmvhrrllkddargvgeplnkegsglwvrgrh
lvlldkketaaarhrlqaemevlapqvvlaqgggaryrleka

    Sequence, based on observed residues (ATOM records): (download) 
    >1o7dD (D:)
rdlviqneylrarfdpntgllmelenllllpvrqafywynastgnnlssqasgayifrpn
qnkplfvshwaqthlvkaslvqevhqnfsawcsqvvrlyprqrhlelewtvgpipvgdgw
gkevisrfdtalatrglfytdsngreilerrrnyrptwklnqtepvagnyypvnsriyit
dgnmqltvltdrsqggsslrdgslelmvhrrllkddargvgeplnkegsglwvrgrhlvl
ldkketaaarhrlqaemevlapqvvlaqgg

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1o7dE (E:)
prtqfsglrrelppsvrlltlarwgpetlllrlehqfavgedsgrnlsspvtldltnlfs
aftitnlrettlaanqllayasrlqwttdtgptphpspsrpvsatitlqpmeirtflasv
qweedg

    Sequence, based on observed residues (ATOM records): (download) 
    >1o7dE (E:)
prtqfsglrrelppsvrlltlarwgpetlllrlehqfavgedsgrnlsspvtldltnlfs
aftitnlrettlaanqllayasrlqwttdatitlqpmeirtflasvqwe