PDB entry 1o7a

View 1o7a on RCSB PDB site
Description: Human beta-Hexosaminidase B
Class: hydrolase
Keywords: hydrolase, glycosyl hydrolase, hexosaminidase, lysosomal, sphingolipid degradation, sandhoff disease, ba8-barrel, glycosidase
Deposited on 2002-10-29, released 2003-10-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-04-25, with a file datestamp of 2012-04-20.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.196
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: beta-hexosaminidase beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1o7aa1, d1o7aa2
  • Chain 'B':
    Compound: beta-hexosaminidase beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1o7ab1, d1o7ab2
  • Chain 'C':
    Compound: beta-hexosaminidase beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1o7ac1, d1o7ac2
  • Chain 'D':
    Compound: beta-hexosaminidase beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1o7ad1, d1o7ad2
  • Chain 'E':
    Compound: beta-hexosaminidase beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1o7ae1, d1o7ae2
  • Chain 'F':
    Compound: beta-hexosaminidase beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1o7af1, d1o7af2
  • Heterogens: GDL, NAG, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1o7aA (A:)
aarapsvsakpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrry
hgyifgfykwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlk
anrvwgalrgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilk
tldamafnkfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlr
girvlpefdtpghtlswgkgqkdlltpcysrqnkldsfgpinptlnttysflttffkeis
evfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkg
sivwqevfddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwr
kyykvepldfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrd
mddaydrltrhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >1o7aA (A:)
palwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqql
lvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtf
tinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyq
sitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdllt
pcyskldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdf
mrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsayp
eelsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwg
eyvdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagy
cnhe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1o7aB (B:)
aarapsvsakpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrry
hgyifgfykwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlk
anrvwgalrgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilk
tldamafnkfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlr
girvlpefdtpghtlswgkgqkdlltpcysrqnkldsfgpinptlnttysflttffkeis
evfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkg
sivwqevfddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwr
kyykvepldfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrd
mddaydrltrhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >1o7aB (B:)
palwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqql
lvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtf
tinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyq
sitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdllt
pcyskldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdf
mrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsayp
eelsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwg
eyvdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagy
cnhe

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1o7aC (C:)
aarapsvsakpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrry
hgyifgfykwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlk
anrvwgalrgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilk
tldamafnkfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlr
girvlpefdtpghtlswgkgqkdlltpcysrqnkldsfgpinptlnttysflttffkeis
evfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkg
sivwqevfddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwr
kyykvepldfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrd
mddaydrltrhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >1o7aC (C:)
palwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqql
lvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtf
tinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyq
sitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdllt
pcyskldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdf
mrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsayp
eelsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwg
eyvdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagy
cnhe

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1o7aD (D:)
aarapsvsakpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrry
hgyifgfykwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlk
anrvwgalrgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilk
tldamafnkfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlr
girvlpefdtpghtlswgkgqkdlltpcysrqnkldsfgpinptlnttysflttffkeis
evfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkg
sivwqevfddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwr
kyykvepldfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrd
mddaydrltrhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >1o7aD (D:)
palwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqql
lvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtf
tinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyq
sitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdllt
pcyskldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdf
mrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsayp
eelsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwg
eyvdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagy
cnh

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1o7aE (E:)
aarapsvsakpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrry
hgyifgfykwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlk
anrvwgalrgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilk
tldamafnkfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlr
girvlpefdtpghtlswgkgqkdlltpcysrqnkldsfgpinptlnttysflttffkeis
evfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkg
sivwqevfddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwr
kyykvepldfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrd
mddaydrltrhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >1o7aE (E:)
palwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqql
lvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtf
tinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyq
sitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdllt
pcyskldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdf
mrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsayp
eelsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwg
eyvdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagy
cnhe

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1o7aF (F:)
aarapsvsakpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrry
hgyifgfykwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlk
anrvwgalrgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilk
tldamafnkfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlr
girvlpefdtpghtlswgkgqkdlltpcysrqnkldsfgpinptlnttysflttffkeis
evfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkg
sivwqevfddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwr
kyykvepldfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrd
mddaydrltrhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >1o7aF (F:)
palwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqql
lvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtf
tinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyq
sitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdllt
pcyskldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdf
mrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsayp
eelsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwg
eyvdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagy
cnhe