PDB entry 1o6q

View 1o6q on RCSB PDB site
Description: structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Class: isomerase
Keywords: isomerase, cholesterol biosynthesis, inhibitor, interactions, oxidosqualene cyclase, monotopic membrane protein
Deposited on 2002-10-13, released 2003-10-17
The last revision prior to the SCOP 1.75 freeze date was dated 2003-10-17, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.201
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: squalene--hopene cyclase
    Species: Alicyclobacillus acidocaldarius
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1o6qa1, d1o6qa2
  • Chain 'B':
    Compound: squalene--hopene cyclase
    Species: Alicyclobacillus acidocaldarius
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1o6qb1, d1o6qb2
  • Chain 'C':
    Compound: squalene--hopene cyclase
    Species: Alicyclobacillus acidocaldarius
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1o6qc1, d1o6qc2
  • Heterogens: C8E, R17, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1o6qA (A:)
maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
fpgdfylgytmyrhvfptlalgrykqaierr

    Sequence, based on observed residues (ATOM records): (download) 
    >1o6qA (A:)
ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
tmyrhvfptlalgrykqaie

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1o6qB (B:)
maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
fpgdfylgytmyrhvfptlalgrykqaierr

    Sequence, based on observed residues (ATOM records): (download) 
    >1o6qB (B:)
ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
tmyrhvfptlalgrykqaie

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1o6qC (C:)
maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
fpgdfylgytmyrhvfptlalgrykqaierr

    Sequence, based on observed residues (ATOM records): (download) 
    >1o6qC (C:)
ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
tmyrhvfptlalgrykqaie