PDB entry 1o5g
View 1o5g on RCSB PDB site
Description: Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
Class: BLOOD CLOTTING, hydrolase
Keywords: Ala190 uPA, S1 site, selectivity, conserved water displacement
hydrogen bond deficit, trypsin, thrombin, hepsin, factor VIIa
Deposited on
2003-09-09, released
2004-09-21
The last revision prior to the SCOP 1.75 freeze date was dated
2005-05-10, with a file datestamp of
2007-06-28.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.208
AEROSPACI score: 0.57
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'H':
Compound: Prothrombin
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d1o5g.1 - Chain 'I':
Compound: Hirudin IIIB'
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: Prothrombin
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d1o5g.1 - Heterogens: NA, CA, CR9, HOH
PDB Chain Sequences:
- Chain 'H':
Sequence, based on SEQRES records: (download)
>1o5gH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge
Sequence, based on observed residues (ATOM records): (download)
>1o5gH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketgqpsvlqvvnlpiverpvckdstriritdnmfc
agykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlk
kwiqkvidqf
- Chain 'I':
No sequence available.
- Chain 'L':
Sequence, based on SEQRES records: (download)
>1o5gL (L:)
tfgsgeadcglrplfekksledkterellesyidgr
Sequence, based on observed residues (ATOM records): (download)
>1o5gL (L:)
tfgsgeadcglrplfekksledkterellesyi