PDB entry 1o5f

View 1o5f on RCSB PDB site
Description: Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
Class: serine protease, hydrolase
Keywords: srcr, scavenger receptor cysteine-rich domain, serine protease Ala190 uPA, S1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor VIIa, serine protease, hydrolase
Deposited on 2003-09-09, released 2004-09-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.78 Å
R-factor: 0.193
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Serine protease hepsin
    Species: Homo sapiens [TaxId:9606]
    Gene: HPN OR TMPRSS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1o5fh_
  • Chain 'L':
    Compound: Serine protease hepsin
    Species: Homo sapiens [TaxId:9606]
    Gene: HPN OR TMPRSS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05981 (Start-113)
      • engineered (66)
    Domains in SCOPe 2.08: d1o5fl_
  • Heterogens: CR9, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1o5fH (H:)
ivggrdtslgrwpwqvslrydgahlcggsllsgdwvltaahcfpernrvlsrwrvfagav
aqasphglqlgvqavvyhggylpfrdpnseensndialvhlssplplteyiqpvclpaag
qalvdgkictvtgwgntqyygqqagvlqearvpiisndvcngadfygnqikpkmfcagyp
eggidacqgdsggpfvcedsisrtprwrlcgivswgtgcalaqkpgvytkvsdfrewifq
aikthseasgmvtql

    Sequence, based on observed residues (ATOM records): (download) 
    >1o5fH (H:)
ivggrdtslgrwpwqvslrydgahlcggsllsgdwvltaahcfpernrvlsrwrvfagav
aqasphglqlgvqavvyhggylpfnsndialvhlssplplteyiqpvclpaagqalvdgk
ictvtgwgntqyygqqagvlqearvpiisndvcngadfygnqikpkmfcagypeggidac
qgdsggpfvcedsisrtprwrlcgivswgtgcalaqkpgvytkvsdfrewifqaikthse
asgmvtql

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1o5fL (L:)
sdqeplypvqvssadarlmvfdktegtwrllcssrsnarvaglsceemgflralthseld
vrtagaagtsgffcvdegrlphtqrllevisvcdcprgrflaaicqdcgrrklp

    Sequence, based on observed residues (ATOM records): (download) 
    >1o5fL (L:)
plypvqvssadarlmvfdktegtwrllcssrsnarvaglsceemgflralthseldvrta
gaagtsgffcvdegrlphtqrllevisvcdcprgrflaaicqdcgrrklp