SCOP 1.75: Structural Classification of Proteins

PDB entry 1o5b

View 1o5b on RCSB PDB site
Description: Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
Class: BLOOD CLOTTING, hydrolase
Keywords: Ala190 uPA, S1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor VIIa
Deposited on 2003-09-09, released 2004-09-21
The last revision prior to the SCOP 1.75 freeze date was dated 2005-03-29, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.197
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: urokinase-type plasminogen activator
Species: HOMO SAPIENS
Gene: PLAU
Database cross-references and differences (RAF-indexed):
- Uniprot P00749
Domains in SCOP 1.75: d1o5b.1
Chain 'B':
Compound: urokinase-type plasminogen activator
Species: HOMO SAPIENS
Gene: PLAU
Database cross-references and differences (RAF-indexed):
- Uniprot P00749 (0-End)
  - engineered (143)
  - engineered (192)
Domains in SCOP 1.75: d1o5b.1
Heterogens: ESI, CIT, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)
```
>1o5bA (A:)
kpssppeelkfqcgqktlrprfk
```
Sequence, based on observed residues (ATOM records): (download)
```
>1o5bA (A:)
lkfqcgqk
```

Chain 'B':
Sequence, based on SEQRES records: (download)

>1o5bB (B:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslmspcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
clpsmyndpqfgtsceitgfgkeastdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdacqgdsggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irshtkeenglal

Sequence, based on observed residues (ATOM records): (download)

>1o5bB (B:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslmspcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
clpsmyndpqfgtsceitgfgkeastdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdacqgdsggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irsht