PDB entry 1o5b
View 1o5b on RCSB PDB site
Description: Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
Class: BLOOD CLOTTING, hydrolase
Keywords: Ala190 uPA, S1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor VIIa, BLOOD CLOTTING, hydrolase
Deposited on
2003-09-09, released
2004-09-21
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.197
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: urokinase-type plasminogen activator
Species: Homo sapiens [TaxId:9606]
Gene: PLAU
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1o5b.1 - Chain 'B':
Compound: urokinase-type plasminogen activator
Species: Homo sapiens [TaxId:9606]
Gene: PLAU
Database cross-references and differences (RAF-indexed):
- Uniprot P00749 (0-End)
- engineered (143)
- engineered (192)
Domains in SCOPe 2.08: d1o5b.1 - Heterogens: ESI, CIT, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1o5bA (A:)
kpssppeelkfqcgqktlrprfk
Sequence, based on observed residues (ATOM records): (download)
>1o5bA (A:)
lkfqcgqk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>1o5bB (B:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslmspcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
clpsmyndpqfgtsceitgfgkeastdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdacqgdsggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irshtkeenglal
Sequence, based on observed residues (ATOM records): (download)
>1o5bB (B:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslmspcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
clpsmyndpqfgtsceitgfgkeastdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdacqgdsggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irsht