PDB entry 1o3p

View 1o3p on RCSB PDB site
Description: Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
Class: BLOOD CLOTTING, hydrolase
Keywords: serine protease, short hydrogen bond, inhibition mechanism, shift of pKa, trypsin, thrombin, urokinase, factor Xa
Deposited on 2003-03-06, released 2003-09-02
The last revision prior to the SCOP 1.75 freeze date was dated 2003-09-02, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 1.81 Å
R-factor: 0.191
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: urokinase-type plasminogen activator
    Species: HOMO SAPIENS
    Gene: PLAU
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1o3p.1
  • Chain 'B':
    Compound: urokinase-type plasminogen activator
    Species: HOMO SAPIENS
    Gene: PLAU
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00749 (0-End)
      • engineered (143)
    Domains in SCOP 1.75: d1o3p.1
  • Heterogens: CIT, 655, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1o3pA (A:)
kpssppeelkfqcgqktlrprfk

    Sequence, based on observed residues (ATOM records): (download) 
    >1o3pA (A:)
lkfqcgqk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1o3pB (B:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslmspcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
clpsmyndpqfgtsceitgfgkeastdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdscqgdsggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irshtkeenglal

    Sequence, based on observed residues (ATOM records): (download) 
    >1o3pB (B:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslmspcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
clpsmyndpqfgtsceitgfgkeastdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdscqgdsggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irshtk