SCOPe 2.05: Structural Classification of Proteins

PDB entry 1nxk

View 1nxk on RCSB PDB site
Description: Crystal structure of staurosporine bound to MAP KAP kinase 2
Class: transferase
Keywords: protein kinase, mk2, phosphorylation, staurosporine, transferase
Deposited on 2003-02-10, released 2003-10-14
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.239
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
  - modified residue (93)
  - modified residue (137)
  - modified residue (166)
  - modified residue (245)
  - modified residue (252)
  - modified residue (274)
  - modified residue (280)
  - modified residue (299)
  - modified residue (313)
  - modified residue (319)
  - modified residue (325)
Domains in SCOPe 2.05: d1nxka_
Chain 'B':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
  - modified residue (93)
  - modified residue (137)
  - modified residue (166)
  - modified residue (245)
  - modified residue (252)
  - modified residue (274)
  - modified residue (280)
  - modified residue (299)
  - modified residue (313)
  - modified residue (319)
  - modified residue (325)
Domains in SCOPe 2.05: d1nxkb_
Chain 'C':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
  - modified residue (93)
  - modified residue (137)
  - modified residue (166)
  - modified residue (245)
  - modified residue (252)
  - modified residue (274)
  - modified residue (280)
  - modified residue (299)
  - modified residue (313)
  - modified residue (319)
  - modified residue (325)
  - modified residue (355)
Domains in SCOPe 2.05: d1nxkc_
Chain 'D':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
  - modified residue (93)
  - modified residue (137)
  - modified residue (166)
  - modified residue (245)
  - modified residue (252)
  - modified residue (274)
  - modified residue (280)
  - modified residue (299)
  - modified residue (313)
  - modified residue (319)
  - modified residue (325)
Domains in SCOPe 2.05: d1nxkd_
Heterogens: SO4, STU, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>1nxkA (A:)
mlsnsqgqsppvpfpapapppqpptpalphppaqppppppqqfpqfhvksglqikknaii
ddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrevelhwrasqcphivri
vdvyenlyagrkcllivmecldggelfsriqdrgdqaftereaseimksigeaiqylhsi
niahrdvkpenllytskrpnailkltdfgfakettshnslttpcytpyyvapevlgpeky
dkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpewsevseevkm
lirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedkerwedvkeemtsal
atmrvdyeqikikkiedasnplllkrrkkaraleaaalah

Sequence, based on observed residues (ATOM records): (download)

>1nxkA (A:)
qfpqfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpka
rrevelhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdraftereas
eimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettpyyvapevl
gpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpewsevs
eevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlked

Chain 'B':
Sequence, based on SEQRES records: (download)

>1nxkB (B:)
mlsnsqgqsppvpfpapapppqpptpalphppaqppppppqqfpqfhvksglqikknaii
ddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrevelhwrasqcphivri
vdvyenlyagrkcllivmecldggelfsriqdrgdqaftereaseimksigeaiqylhsi
niahrdvkpenllytskrpnailkltdfgfakettshnslttpcytpyyvapevlgpeky
dkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpewsevseevkm
lirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedkerwedvkeemtsal
atmrvdyeqikikkiedasnplllkrrkkaraleaaalah

Sequence, based on observed residues (ATOM records): (download)

>1nxkB (B:)
pqfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarr
evelhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafterea
seimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettpyyvapev
lgpekydkscdmwslgvimyillcgyppfysgmktrirmgqyefpnpewsevseevkmli
rnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlked

Chain 'C':
Sequence, based on SEQRES records: (download)

>1nxkC (C:)
mlsnsqgqsppvpfpapapppqpptpalphppaqppppppqqfpqfhvksglqikknaii
ddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrevelhwrasqcphivri
vdvyenlyagrkcllivmecldggelfsriqdrgdqaftereaseimksigeaiqylhsi
niahrdvkpenllytskrpnailkltdfgfakettshnslttpcytpyyvapevlgpeky
dkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpewsevseevkm
lirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedkerwedvkeemtsal
atmrvdyeqikikkiedasnplllkrrkkaraleaaalah

Sequence, based on observed residues (ATOM records): (download)

>1nxkC (C:)
qqfpqfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpk
arrevelhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafte
reaseimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettpyyva
pevlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpew
sevseevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedkerwed
vkeemt

Chain 'D':
Sequence, based on SEQRES records: (download)

>1nxkD (D:)
mlsnsqgqsppvpfpapapppqpptpalphppaqppppppqqfpqfhvksglqikknaii
ddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrevelhwrasqcphivri
vdvyenlyagrkcllivmecldggelfsriqdrgdqaftereaseimksigeaiqylhsi
niahrdvkpenllytskrpnailkltdfgfakettshnslttpcytpyyvapevlgpeky
dkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpewsevseevkm
lirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedkerwedvkeemtsal
atmrvdyeqikikkiedasnplllkrrkkaraleaaalah

Sequence, based on observed residues (ATOM records): (download)

>1nxkD (D:)
fpqfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkar
revelhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrftereasei
mksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettcytpyyvapev
lgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpewsev
seevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvl