PDB entry 1nw3

View 1nw3 on RCSB PDB site
Description: Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase
Class: transferase
Keywords: hDot1, histone lysine methyltransferase, TRANSFERASE
Deposited on 2003-02-05, released 2003-03-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-04-16, with a file datestamp of 2014-04-11.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.204
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: histone methyltransferase DOT1L
    Species: Homo sapiens [TaxId:9606]
    Gene: dot1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1nw3a_
  • Heterogens: ACT, SO4, SAM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1nw3A (A:)
mgeklelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvl
idydtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvt
dpeklnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnck
hhygvekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifv
nnfafgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplk
gsvswtgkpvsyylhtidrtilenyfsslknpklreeqeaarrrqqresksnaatptkgp
egkvagpadapmdsgaeeekagaatvkkpspskarkkklnkkgrkmagrkrgrpkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1nw3A (A:)
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpek
lnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhyg
vekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfa
fgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvs
wtgkpvsyylhtidrtilenyfsslknp