PDB entry 1nvw
View 1nvw on RCSB PDB site
Description: Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
Class: signaling protein
Keywords: Proto-oncogene, GTP-binding, Guanine-nucleotide releasing factor, SIGNALING PROTEIN
Deposited on
2003-02-04, released
2003-04-01
The last revision prior to the SCOPe 2.07 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.209
AEROSPACI score: 0.28
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'Q':
Compound: transforming protein p21/h-ras-1
Species: Homo sapiens [TaxId:9606]
Gene: HRAS OR HRAS1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1nvwq_ - Chain 'R':
Compound: transforming protein p21/h-ras-1
Species: Homo sapiens [TaxId:9606]
Gene: HRAS OR HRAS1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1nvwr_ - Chain 'S':
Compound: Son of sevenless protein homolog 1
Species: Homo sapiens [TaxId:9606]
Gene: SOS1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1nvws_ - Heterogens: MG, PO4, GNP, HOH
PDB Chain Sequences:
- Chain 'Q':
Sequence; same for both SEQRES and ATOM records: (download)
>1nvwQ (Q:)
mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
- Chain 'R':
Sequence; same for both SEQRES and ATOM records: (download)
>1nvwR (R:)
mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
- Chain 'S':
Sequence, based on SEQRES records: (download)
>1nvwS (S:)
qmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfvr
tflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpv
qlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiard
ngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselv
gsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqel
nnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinpp
cvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrves
dikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnp
r
Sequence, based on observed residues (ATOM records): (download)
>1nvwS (S:)
qmrlpsadvyrfaepdseeniifeegipiikagtviklierltyhmyadpnfvrtfltty
rsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlrvln
vcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiahnitfqss
pptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkein
spnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsa
mnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltni
lkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpm
gnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnpr