PDB entry 1np0

View 1np0 on RCSB PDB site
Description: Human lysosomal beta-hexosaminidase isoform B in complex with intermediate analogue NAG-thiazoline
Class: hydrolase
Keywords: (beta/alpha)8-barrel, homodimer, family 20 glycosidase
Deposited on 2003-01-16, released 2003-04-29
The last revision prior to the SCOP 1.75 freeze date was dated 2003-04-29, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.2
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: beta-hexosaminidase beta chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1np0a1, d1np0a2
  • Chain 'B':
    Compound: beta-hexosaminidase beta chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1np0b1, d1np0b2
  • Heterogens: SO4, NGT, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1np0A (A:)
akpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgfy
kwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlkanrvwgal
rgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilktldamafn
kfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpef
dtpghtlswgkgqkdlltpcysrqnkldsfgpinptlnttysflttffkeisevfpdqfi
hlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevf
ddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwrkyykvepl
dfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrdmddaydrl
trhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >1np0A (A:)
alwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqqll
vsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtft
inestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqs
itfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltp
cysldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmr
qkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypee
lsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgey
vdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1np0B (B:)
akpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgfy
kwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlkanrvwgal
rgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilktldamafn
kfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpef
dtpghtlswgkgqkdlltpcysrqnkldsfgpinptlnttysflttffkeisevfpdqfi
hlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevf
ddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwrkyykvepl
dfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrdmddaydrl
trhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >1np0B (B:)
alwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqqll
vsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtft
inestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqs
itfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltp
cysldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmr
qkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypee
lsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgey
vdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn