PDB entry 1np0

View 1np0 on RCSB PDB site
Description: Human lysosomal beta-hexosaminidase isoform B in complex with intermediate analogue NAG-thiazoline
Class: hydrolase
Keywords: (beta/alpha)8-barrel, homodimer, family 20 glycosidase, HYDROLASE
Deposited on 2003-01-16, released 2003-04-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-hexosaminidase subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1np0.1
  • Chain 'B':
    Compound: Beta-hexosaminidase subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1np0.2
  • Chain 'C':
    Compound: Beta-hexosaminidase subunit beta chain B
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1np0.1, d1np0.3
  • Chain 'D':
    Compound: Beta-hexosaminidase subunit beta chain A
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1np0.3
  • Chain 'E':
    Compound: Beta-hexosaminidase subunit beta chain B
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1np0.2, d1np0.4
  • Chain 'F':
    Compound: Beta-hexosaminidase subunit beta chain A
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1np0.4
  • Heterogens: NGT, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1np0A (A:)
akpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifg

    Sequence, based on observed residues (ATOM records): (download) 
    >1np0A (A:)
alwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1np0B (B:)
akpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifg

    Sequence, based on observed residues (ATOM records): (download) 
    >1np0B (B:)
alwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifg

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1np0C (C:)
tqvqqllvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyq
dsygtftinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivdd
qsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkg
qkdlltpcys

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1np0D (D:)
ldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkg
fgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsr
vtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvda
tnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycnhen
m

    Sequence, based on observed residues (ATOM records): (download) 
    >1np0D (D:)
ldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkg
fgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsr
vtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvda
tnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1np0E (E:)
tqvqqllvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyq
dsygtftinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivdd
qsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkg
qkdlltpcys

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1np0F (F:)
ldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkg
fgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsr
vtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvda
tnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycnhen
m

    Sequence, based on observed residues (ATOM records): (download) 
    >1np0F (F:)
ldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkg
fgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsr
vtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvda
tnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn