PDB entry 1no9
View 1no9 on RCSB PDB site
Description: Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.
Class: hydrolase
Keywords: complex (serine protease/inhibitor), blood coagulation,
serine proteinase inhibition,
n,n-diphenylcarbamoyl-aminoguanidine
Deposited on
2003-01-16, released
2003-08-26
The last revision prior to the SCOP 1.75 freeze date was dated
2003-08-26, with a file datestamp of
2007-07-20.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.183
AEROSPACI score: 0.6
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'H':
Compound: alpha thrombin
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d1no9.1 - Chain 'I':
Compound: hirugen
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: alpha thrombin
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d1no9.1 - Heterogens: NAG, 4ND, HOH
PDB Chain Sequences:
- Chain 'H':
Sequence, based on SEQRES records: (download)
>1no9H (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge
Sequence, based on observed residues (ATOM records): (download)
>1no9H (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwgqpsvlqvvnlpiverpvckdstriritdnmf
cagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrl
kkwiqkvidqfge
- Chain 'I':
No sequence available.
- Chain 'L':
Sequence; same for both SEQRES and ATOM records: (download)
>1no9L (L:)
tfgsgeadcglrplfekksledkterellesyidgr