PDB entry 1ni4
View 1ni4 on RCSB PDB site
Description: human pyruvate dehydrogenase
Class: oxidoreductase
Keywords: thiamin pyrophosphate, pyruvate, alpha-keto acid dehydrogenase, pyruvate dehydrogenase, oxidoreductase
Deposited on
2002-12-20, released
2003-06-17
The last revision prior to the SCOPe 2.03 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.202
AEROSPACI score: 0.43
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Pyruvate dehydrogenase E1 component: Alpha subunit
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P08559 (4-364)
- cloning artifact (3)
- modified residue (41-42)
- modified residue (48)
- modified residue (127)
- modified residue (129)
- modified residue (184)
- modified residue (203)
- modified residue (231)
- modified residue (256)
- modified residue (268)
- modified residue (292)
- modified residue (298)
Domains in SCOPe 2.03: d1ni4a_ - Chain 'B':
Compound: Pyruvate dehydrogenase E1 component: Beta subunit
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P11177 (12-340)
- cloning artifact (11)
- see remark 999 (12)
- modified residue (24)
- modified residue (71)
- modified residue (82)
- modified residue (92)
- modified residue (98)
- modified residue (114)
- modified residue (186)
- modified residue (249)
- modified residue (255)
- modified residue (257)
- modified residue (265)
- modified residue (291)
- modified residue (313)
Domains in SCOPe 2.03: d1ni4b1, d1ni4b2 - Chain 'C':
Compound: Pyruvate dehydrogenase E1 component: Alpha subunit
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P08559 (4-364)
- cloning artifact (3)
- modified residue (41-42)
- modified residue (48)
- modified residue (127)
- modified residue (129)
- modified residue (184)
- modified residue (203)
- modified residue (231)
- modified residue (256)
- modified residue (268)
- modified residue (292)
- modified residue (298)
Domains in SCOPe 2.03: d1ni4c_ - Chain 'D':
Compound: Pyruvate dehydrogenase E1 component: Beta subunit
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P11177 (12-340)
- cloning artifact (11)
- see remark 999 (12)
- modified residue (24)
- modified residue (71)
- modified residue (82)
- modified residue (92)
- modified residue (98)
- modified residue (114)
- modified residue (186)
- modified residue (249)
- modified residue (255)
- modified residue (257)
- modified residue (265)
- modified residue (291)
- modified residue (313)
Domains in SCOPe 2.03: d1ni4d1, d1ni4d2 - Heterogens: MG, K, TPP, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1ni4A (A:)
mrgsfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqk
iirgfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggc
akgkggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqif
eaynmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvrea
trfaaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiqevrsksdpimllkdrmv
nsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwik
fksvs
Sequence, based on observed residues (ATOM records): (download)
>1ni4A (A:)
sfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
nmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatrf
aaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiqevrsksdpimllkdrmvnsn
lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
vs
- Chain 'B':
Sequence, based on SEQRES records: (download)
>1ni4B (B:)
mrgshhhhhhgslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkyg
dkriidtpisemgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglq
pvpivfrgpngasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvv
vlenelmygvpfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlsk
egvecevinmrtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfl
dapavrvtgadvpmpyakilednsipqvkdiifaikktlni
Sequence, based on observed residues (ATOM records): (download)
>1ni4B (B:)
slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
fefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmr
tirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgad
vpmpyakilednsipqvkdiifaikktlni
- Chain 'C':
Sequence, based on SEQRES records: (download)
>1ni4C (C:)
mrgsfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqk
iirgfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggc
akgkggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqif
eaynmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvrea
trfaaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiqevrsksdpimllkdrmv
nsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwik
fksvs
Sequence, based on observed residues (ATOM records): (download)
>1ni4C (C:)
sfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
nmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatrf
aaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiqevrsksdpimllkdrmvnsn
lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
vs
- Chain 'D':
Sequence, based on SEQRES records: (download)
>1ni4D (D:)
mrgshhhhhhgslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkyg
dkriidtpisemgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglq
pvpivfrgpngasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvv
vlenelmygvpfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlsk
egvecevinmrtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfl
dapavrvtgadvpmpyakilednsipqvkdiifaikktlni
Sequence, based on observed residues (ATOM records): (download)
>1ni4D (D:)
slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
fefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmr
tirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgad
vpmpyakilednsipqvkdiifaikktlni