PDB entry 1ni4

View 1ni4 on RCSB PDB site
Description: human pyruvate dehydrogenase
Class: oxidoreductase
Keywords: thiamin pyrophosphate, pyruvate, alpha-keto acid dehydrogenase, pyruvate dehydrogenase, oxidoreductase
Deposited on 2002-12-20, released 2003-06-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.202
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate dehydrogenase E1 component: Alpha subunit
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (4-364)
      • cloning artifact (3)
      • modified residue (41-42)
      • modified residue (48)
      • modified residue (127)
      • modified residue (129)
      • modified residue (184)
      • modified residue (203)
      • modified residue (231)
      • modified residue (256)
      • modified residue (268)
      • modified residue (292)
      • modified residue (298)
    Domains in SCOPe 2.07: d1ni4a1, d1ni4a2
  • Chain 'B':
    Compound: Pyruvate dehydrogenase E1 component: Beta subunit
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11177 (12-340)
      • cloning artifact (11)
      • see remark 999 (12)
      • modified residue (24)
      • modified residue (71)
      • modified residue (82)
      • modified residue (92)
      • modified residue (98)
      • modified residue (114)
      • modified residue (186)
      • modified residue (249)
      • modified residue (255)
      • modified residue (257)
      • modified residue (265)
      • modified residue (291)
      • modified residue (313)
    Domains in SCOPe 2.07: d1ni4b1, d1ni4b2, d1ni4b3
  • Chain 'C':
    Compound: Pyruvate dehydrogenase E1 component: Alpha subunit
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (4-364)
      • cloning artifact (3)
      • modified residue (41-42)
      • modified residue (48)
      • modified residue (127)
      • modified residue (129)
      • modified residue (184)
      • modified residue (203)
      • modified residue (231)
      • modified residue (256)
      • modified residue (268)
      • modified residue (292)
      • modified residue (298)
    Domains in SCOPe 2.07: d1ni4c1, d1ni4c2
  • Chain 'D':
    Compound: Pyruvate dehydrogenase E1 component: Beta subunit
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11177 (12-340)
      • cloning artifact (11)
      • see remark 999 (12)
      • modified residue (24)
      • modified residue (71)
      • modified residue (82)
      • modified residue (92)
      • modified residue (98)
      • modified residue (114)
      • modified residue (186)
      • modified residue (249)
      • modified residue (255)
      • modified residue (257)
      • modified residue (265)
      • modified residue (291)
      • modified residue (313)
    Domains in SCOPe 2.07: d1ni4d1, d1ni4d2, d1ni4d3
  • Heterogens: MG, K, TPP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1ni4A (A:)
    mrgsfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqk
    iirgfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggc
    akgkggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqif
    eaynmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvrea
    trfaaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiqevrsksdpimllkdrmv
    nsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwik
    fksvs
    

    Sequence, based on observed residues (ATOM records): (download)
    >1ni4A (A:)
    sfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
    gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
    kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
    nmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatrf
    aaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiqevrsksdpimllkdrmvnsn
    lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
    vs
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1ni4B (B:)
    mrgshhhhhhgslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkyg
    dkriidtpisemgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglq
    pvpivfrgpngasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvv
    vlenelmygvpfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlsk
    egvecevinmrtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfl
    dapavrvtgadvpmpyakilednsipqvkdiifaikktlni
    

    Sequence, based on observed residues (ATOM records): (download)
    >1ni4B (B:)
    slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
    mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
    asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
    fefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmr
    tirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgad
    vpmpyakilednsipqvkdiifaikktlni
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1ni4C (C:)
    mrgsfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqk
    iirgfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggc
    akgkggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqif
    eaynmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvrea
    trfaaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiqevrsksdpimllkdrmv
    nsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwik
    fksvs
    

    Sequence, based on observed residues (ATOM records): (download)
    >1ni4C (C:)
    sfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
    gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
    kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
    nmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatrf
    aaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiqevrsksdpimllkdrmvnsn
    lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
    vs
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1ni4D (D:)
    mrgshhhhhhgslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkyg
    dkriidtpisemgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglq
    pvpivfrgpngasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvv
    vlenelmygvpfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlsk
    egvecevinmrtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfl
    dapavrvtgadvpmpyakilednsipqvkdiifaikktlni
    

    Sequence, based on observed residues (ATOM records): (download)
    >1ni4D (D:)
    slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
    mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
    asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
    fefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmr
    tirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgad
    vpmpyakilednsipqvkdiifaikktlni