PDB entry 1n8z

View 1n8z on RCSB PDB site
Description: Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab
Class: transferase
Keywords: tyrosin kinase receptor, cell surface receptor, TRANSFERASE
Deposited on 2002-11-21, released 2003-02-18
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.52 Å
R-factor: 0.225
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Herceptin Fab (antibody) - light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1N8Z (0-213)
    Domains in SCOPe 2.01: d1n8za1, d1n8za2
  • Chain 'B':
    Compound: Herceptin Fab (antibody) - heavy chain
    Database cross-references and differences (RAF-indexed):
    • PDB 1N8Z (0-219)
    Domains in SCOPe 2.01: d1n8zb1, d1n8zb2
  • Chain 'C':
    Compound: Receptor protein-tyrosine kinase erbB-2
    Species: Homo sapiens [TaxId:9606]
    Gene: HER2(erbB2)
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1n8zc1, d1n8zc2, d1n8zc3, d1n8zc4
  • Heterogens: NAG, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1n8zA (A:)
diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysasflysgvps
rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1n8zB (B:)
evqlvesggglvqpggslrlscaasgfnikdtyihwvrqapgkglewvariyptngytry
adsvkgrftisadtskntaylqmnslraedtavyycsrwggdgfyamdywgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1n8zC (C:)
tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplnnttpvtgaspgglrelql
rslteilkggvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgs
rcwgessedcqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsg
icelhcpalvtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqev
taedgtqrcekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfd
gdpasntaplqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngays
ltlqglgiswlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrped
ecvgeglachqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclp
chpecqpqngsvtcfgpeadqcvacahykdppfcvarcpsgvkpdlsympiwkfpdeega
cqpcpin

    Sequence, based on observed residues (ATOM records): (download) 
    >1n8zC (C:)
tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplspgglrelqlrslteilkg
gvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsrcwgessed
cqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgicelhcpal
vtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevtatqrcekc
skpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdsntaplqpeqlq
vfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgiswlglrsl
relgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgeglachqlcarg
hcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpchpecqpqngsvtcfg
peadqcvacahykdppfcvarcpsiwkfpdeegacqpcpin