PDB entry 1n8z

View 1n8z on RCSB PDB site
Description: Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab
Class: transferase
Keywords: tyrosin kinase receptor, cell surface receptor
Deposited on 2002-11-21, released 2003-02-18
The last revision prior to the SCOP 1.75 freeze date was dated 2003-02-18, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.52 Å
R-factor: 0.225
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Herceptin Fab (antibody) - light chain
    Species: HOMO SAPIENS
    Domains in SCOP 1.75: d1n8za1, d1n8za2
  • Chain 'B':
    Compound: Herceptin Fab (antibody) - heavy chain
    Domains in SCOP 1.75: d1n8zb1, d1n8zb2
  • Chain 'C':
    Compound: Receptor protein-tyrosine kinase erbB-2
    Species: HOMO SAPIENS
    Gene: HER2(erbB2)
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1n8zc1, d1n8zc2, d1n8zc3, d1n8zc4
  • Heterogens: NAG, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1n8zA (A:)
    diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysasflysgvps
    rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1n8zB (B:)
    evqlvesggglvqpggslrlscaasgfnikdtyihwvrqapgkglewvariyptngytry
    adsvkgrftisadtskntaylqmnslraedtavyycsrwggdgfyamdywgqgtlvtvss
    astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
    glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1n8zC (C:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplnnttpvtgaspgglrelql
    rslteilkggvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgs
    rcwgessedcqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsg
    icelhcpalvtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqev
    taedgtqrcekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfd
    gdpasntaplqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngays
    ltlqglgiswlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrped
    ecvgeglachqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclp
    chpecqpqngsvtcfgpeadqcvacahykdppfcvarcpsgvkpdlsympiwkfpdeega
    cqpcpin
    

    Sequence, based on observed residues (ATOM records): (download)
    >1n8zC (C:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplspgglrelqlrslteilkg
    gvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsrcwgessed
    cqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgicelhcpal
    vtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevtatqrcekc
    skpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdsntaplqpeqlq
    vfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgiswlglrsl
    relgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgeglachqlcarg
    hcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpchpecqpqngsvtcfg
    peadqcvacahykdppfcvarcpsiwkfpdeegacqpcpin