PDB entry 1n1l

View 1n1l on RCSB PDB site
Description: crystal structure of hcv ns3 protease domain:ns4a peptide complex with covalently bound inhibitor (gw472467x)
Class: Viral protein
Keywords: viral protein, serine protease, nonstructural proteins, cofactor peptide, helicase, inhibitor
Deposited on 2002-10-18, released 2003-10-21
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.185
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hcv ns3 serine protease
    Species: Hepatitis C virus [TaxId:11103]
    Gene: H STRAIN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27958 (10-189)
      • engineered (173)
    Domains in SCOPe 2.06: d1n1l.1
  • Chain 'B':
    Compound: hcv ns3 serine protease
    Species: Hepatitis C virus [TaxId:11103]
    Gene: H STRAIN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27958 (Start-189)
      • engineered (173)
    Domains in SCOPe 2.06: d1n1l.2
  • Chain 'C':
    Compound: ns4a cofactor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • GB CAB53095 (2-20)
      • cloning artifact (1)
      • cloning artifact (21)
    Domains in SCOPe 2.06: d1n1l.1
  • Chain 'D':
    Compound: ns4a cofactor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • GB CAB53095 (2-End)
    Domains in SCOPe 2.06: d1n1l.2
  • Heterogens: ZN, TRL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1n1lA (A:)
asmtggqqmgapitayaqqtrgllgciitsltgrdknqvegevqivstatqtflatcing
vcwtvyhgagtrtiaspkgpviqmytnvdqdlvgwpapqgsrsltpctcgssdlylvtrh
advipvrrrgdsrgsllsprpisylkgssggpllcpaghavglfraavctrgvtkavdfi
pvenlettmrgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >1n1lA (A:)
apitayaqqtrgllgciitsltgrdknqvegevqivstatqtflatcingvcwtvyhgag
trtiaspkgpviqmytnvdqdlvgwpapqgsrsltpctcgssdlylvtrhadvipvrrrg
dsrgsllsprpisylkgssggpllcpaghavglfraavctrgvtkavdfipvenlettmr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1n1lB (B:)
asmtggqqmgapitayaqqtrgllgciitsltgrdknqvegevqivstatqtflatcing
vcwtvyhgagtrtiaspkgpviqmytnvdqdlvgwpapqgsrsltpctcgssdlylvtrh
advipvrrrgdsrgsllsprpisylkgssggpllcpaghavglfraavctrgvtkavdfi
pvenlettmrgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >1n1lB (B:)
qvegevqivstatqtflatcingvcwtvyhgagtrtiaspkgpviqmytnvdqdlvgwpa
pqgsrsltpctcgssdlylvtrhadvipvrrrgdsrgsllsprpisylkgssggpllcpa
ghavglfraavctrgvtkavdfipvenlettmr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1n1lC (C:)
kkgsvvivgrivlsgkpaiipkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1n1lC (C:)
kgsvvivgrivlsgkpaiipk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1n1lD (D:)
kkgsvvivgrivlsgkpaiipkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1n1lD (D:)
gsvvivgrivlsgkpa