PDB entry 1mw8

View 1mw8 on RCSB PDB site
Description: Crystal Structure of a Complex between H365R mutant of 67 kDA N-terminal fragment of E. coli DNA Topoisomerase I and 5'-ACTTCGGGATG-3'
Class: isomerase
Keywords: DNA topoisomerase, decatenase enzyme, toprim domain, isomerase
Deposited on 2002-09-27, released 2003-10-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-24, with a file datestamp of 2019-07-19.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'X':
    Compound: DNA topoisomerase I
    Species: Escherichia coli [TaxId:562]
    Gene: TOPA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06612 (Start-591)
      • engineered (364)
      • see remark 999 (548)
    Domains in SCOPe 2.08: d1mw8x_
  • Chain 'Y':
    Compound: 5'-d(*ap*cp*tp*tp*cp*gp*gp*gp*ap*tp*g)-3'
  • Heterogens: SO4, TMP, HOH

PDB Chain Sequences:

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >1mw8X (X:)
mgkalvivespakaktinkylgsdyvvkssvghirdlptsgsaakksadststktakkpk
kdergalvnrmgvdpwhnweahyevlpgkekvvselkqlaekadhiylatdldregeaia
whlreviggddarysrvvfneitknairqafnkpgelnidrvnaqqarrfmdrvvgymvs
pllwkkiarglsagrvqsvavrlvverereikafvpeefwevdastttpsgealalqvth
qndkpfrpvnkeqtqaavsllekarysvleredkpttskpgapfitstlqqaastrlgfg
vkktmmmaqrlyeagyitymrtdstnlsqdavnmvrgyisdnfgkkylpespnqyasken
sqeareairpsdvnvmaeslkdmeadaqklyqliwrqfvacqmtpakydsttltvgagdf
rlkargrilrfdgwtkvmpalrkgdedrilpavnkgdaltlveltpaqhftkpparfsea
slvkelekrgigrpstyasiistiqdrgyvrvenrrfyaekmgeivtdrleenfrelmny
dftaqmennldqvanheaewkavldhffsdftqqldkaekdpeeggmrpnqm

    Sequence, based on observed residues (ATOM records): (download) 
    >1mw8X (X:)
gkalvivespakaktinkylgsdyvvkssvghirdlptsgdergalvnrmgvdpwhnwea
hyevlpgkekvvselkqlaekadhiylatdldregeaiawhlreviggddarysrvvfne
itknairqafnkpgelnidrvnaqqarrfmdrvvgymvspllwkkiarglsagrvqsvav
rlvverereikafvpeefwevdastttpsgealalqvthqndkpfrpvnkeqtqaavsll
ekarysvleredkpttskpgapfitstlqqaastrlgfgvkktmmmaqrlyeagyitymr
tdstnlsqdavnmvrgyisdnfgkkylpespnqyaseareairpsdvnvmaeslkdmead
aqklyqliwrqfvacqmtpakydsttltvgagdfrlkargrilrfdgwtkvmpaedrilp
avnkgdaltlveltpaqhftkpparfseaslvkelekrgigrpstyasiistiqdrgyvr
venrrfyaekmgeivtdrleenfrelmnydftaqmennldqvanheaewkavldhffsdf
tqqldkaekdpeeggmrpnqm

  • Chain 'Y':
    No sequence available.