PDB entry 1mu2

View 1mu2 on RCSB PDB site
Description: crystal structure of hiv-2 reverse transcriptase
Class: transferase
Keywords: hiv-2 reverse transcriptase, aids, polymerase, drug design, transferase
Deposited on 2002-09-23, released 2002-10-30
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.192
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hiv-2 rt
    Species: Human immunodeficiency virus 2 [TaxId:11709]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04584 (Start-554)
      • engineered (283)
      • see remark 999 (333)
      • see remark 999 (504)
    Domains in SCOPe 2.07: d1mu2a1, d1mu2a2
  • Chain 'B':
    Compound: hiv-2 rt
    Species: Human immunodeficiency virus 2 [TaxId:11709]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04584 (0-425)
      • engineered (278)
      • see remark 999 (328)
    Domains in SCOPe 2.07: d1mu2b_
  • Heterogens: SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1mu2A (A:)
    pvakvepikimlkpgkdgpklrqwpltkekiealkeicekmekegqleeapptnpyntpt
    faikkkdknkwrmlidfrelnkvtqdfteiqlgiphpaglakkrritvldvgdayfsipl
    hedfrpytaftlpsvnnaepgkryiykvlpqgwkgspaifqhtmrqvlepfrkankdvii
    iqymddiliasdrtdlehdrvvlqlkellnglgfstpdekfqkdppyhwmgyelwptkwk
    lqkiqlpqkeiwtvndiqklvgvlnwaaqlypgiktkhlcrlisgkmtlteevqwtelae
    aeleenriilsqeqeghyyqeekeleatvqkdqdnqwtykihqeekilkvgkyakvknth
    tngirllaqvvqkigkealviwgripkfhlpvereiweqwwdnywqvtwipdwdfvstpp
    lvrlafnlvgdpipgaetfytdgscnrqskegkagyvtdrgkdkvkkleqttnqqaelea
    famaltdsgpkvniivdsqyvmgivasqpteseskivnqiieemikkeaiyvawvpahkg
    iggnqevdhlvsqgi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1mu2A (A:)
    akvepikimlkpgkdgpklrqwpltkekiealkeicekmekegqleeapptnpyntptfa
    ikkkdrmlidfrelnkvtqdfteiqlgiphpaglakkrritvldvgdayfsiplhedfrp
    ytaftlkryiykvlpqgwkgspaifqhtmrqvlepfrkankdviiiqymddiliasdrtd
    lehdrvvlqlkellnglgfstpdekfqkdppyhwmgyelwptkwklqkiqlpqkeiwtvn
    diqklvgvlnwaaqlypgiktkhlcrlisgkmtlteevqwtelaeaeleenriilsqeqe
    ghyyqeekeleatvqkdqdnqwtykihqeekilkvgkyakvthtngirllaqvvqkigke
    alviwgripkfhlpvereiweqwwdnywqvtwipdwdfvstpplvrlafnlvgdpipgae
    tfytdgscnrqskegkagyvtdrgkdkvkkleqttnqqaeleafamaltdsgpkvniivd
    sqyvmgivasqpteseskivnqiieemikkeaiyvawvpahkgiggnqevdhlvsqgi
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1mu2B (B:)
    epikimlkpgkdgpklrqwpltkekiealkeicekmekegqleeapptnpyntptfaikk
    kdknkwrmlidfrelnkvtqdfteiqlgiphpaglakkrritvldvgdayfsiplhedfr
    pytaftlpsvnnaepgkryiykvlpqgwkgspaifqhtmrqvlepfrkankdviiiqymd
    diliasdrtdlehdrvvlqlkellnglgfstpdekfqkdppyhwmgyelwptkwklqkiq
    lpqkeiwtvndiqklvgvlnwaaqlypgiktkhlcrlisgkmtlteevqwtelaeaelee
    nriilsqeqeghyyqeekeleatvqkdqdnqwtykihqeekilkvgkyakvknthtngir
    llaqvvqkigkealviwgripkfhlpvereiweqwwdnywqvtwipdwdfvstpplvrla
    fnlvgd
    

    Sequence, based on observed residues (ATOM records): (download)
    >1mu2B (B:)
    epikimlkpgkdgpklrqwpltkekiealkeicekmekegqleeapptnpyntptfaikn
    kwrmlidfrelnkvtqdfteiqphpaglakkrritvldvgdayfsiplhedfrpytaftl
    psvnnaepgkryiykvlpqgwkgspaifqhtmrqvlepfrkankdviiiqymddiliasd
    rtdlehdrvvlqlkellngwmgyelwptkwklqkiqlpqkeiwtvndiqklvgvlnwaaq
    lypgiktkhlcrlisgkmtlteevqwtelaeaeleenriilsqeqeghyyqeekeleatv
    qkdqdnqwtykihqeekilkvgkyakvknthtngirllaqvvqkigkealviwgripkfh
    lpvereiweqwwdnywqvtwipdwdfvstpplvrlafnlvgd