PDB entry 1mlw

View 1mlw on RCSB PDB site
Description: Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III)
Class: oxidoreductase
Keywords: aromatic amino acid hydroxylase catalytic domain fold, oxidoreductase
Deposited on 2002-08-31, released 2002-12-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.71 Å
R-factor: 0.205
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tryptophan 5-monooxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1mlwa_
  • Heterogens: FE, HBI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1mlwA (A:)
mesvpwfpkkisdldhcanrvlmygseldadhpgfkdnvyrkrrkyfadlamnykhgdpi
pkvefteeeiktwgtvfrelnklypthacreylknlpllskycgyrednipqledvsnfl
kertgfsirpvagylsprdflsglafrvfhctqyvrhssdpfytpepdtchellghvpll
aepsfaqfsqeiglaslgaseeavqklatcyfftvefglckqdgqlrvfgagllssisel
khalsghakvkpfdpkitckqeclittfqdvyfvsesfedakekmreftktikrpfgvky
n

    Sequence, based on observed residues (ATOM records): (download) 
    >1mlwA (A:)
svpwfpkkisdldhcanrvlmygseldadhpgfkdnvyrkrrkyfadlamnykhgdpipk
vefteeeiktwgtvfrelnklypthacreylknlpllskycgyrednipqledvsnflke
rtgfsirpvagylsprdflsglafrvfhctqyvrhssdpfytpepdtchellghvpllae
psfaqfsqeiglaslgaseeavqklatcyfftvefglckqdgqlrvfgagllssiselkh
alsghakvkpfdpkitckqeclittfqdvyfvsesfedakekmreftkti