PDB entry 1mkx

View 1mkx on RCSB PDB site
Description: the co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the yppw segment and active site residues upon ligand binding
Class: complex (blood coagulation/proenzyme)
Keywords: complex (blood coagulation/proenzyme), thrombin, prethrombin-2, plasma, serine protease
Deposited on 1997-03-13, released 1997-07-07
The last revision prior to the SCOP 1.73 freeze date was dated 1997-07-07, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.187
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: alpha-thrombin
    Species: BOS TAURUS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1mkx.1
  • Chain 'K':
    Compound: prethrombin-2
    Species: BOS TAURUS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1mkxk_
  • Chain 'L':
    Compound: alpha-thrombin
    Species: BOS TAURUS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1mkx.1
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1mkxH (H:)
ivegqdaevglspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftvddll
vrigkhsrtryerkvekismldkiyihprynwkenldrdiallklkrpielsdyihpvcl
pdkqtaakllhagfkgrvtgwgnrretwttsvaevqpsvlqvvnlplverpvckastrir
itdnmfcagykpgegkrgdacegdsggpfvmkspynnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidrlgs

    Sequence, based on observed residues (ATOM records): (download) 
    >1mkxH (H:)
ivegqdaevglspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftvddll
vrigkhsrtryerkvekismldkiyihprynwkenldrdiallklkrpielsdyihpvcl
pdkqtaakllhagfkgrvtgwgnrretwttsvaevqpsvlqvvnlplverpvckastrir
itdnmfcagykpgegkrgdacegdsggpfvmkspynnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvid

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >1mkxK (K:)
tsedhfqpffnektfgageadcglrplfekkqvqdqtekelfesyiegrivegqdaevgl
spwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftvddllvrigkhsrtry
erkvekismldkiyihprynwkenldrdiallklkrpielsdyihpvclpdkqtaakllh
agfkgrvtgwgnrretwttsvaevqpsvlqvvnlplverpvckastriritdnmfcagyk
pgegkrgdacegdsggpfvmkspynnrwyqmgivswgegcdrdgkygfythvfrlkkwiq
kvidrlgs

    Sequence, based on observed residues (ATOM records): (download) 
    >1mkxK (K:)
geadcglrplfekkqvqdqtekelfesyiegrivegqdaevglspwqvmlfrkspqellc
gaslisdrwvltaahcllyppwdknftvddllvrigkhsrtryerkvekismldkiyihp
rynwkenldrdiallklkrpielsdyihpvclpdkqtaakllhagfkgrvtgwgnrretw
ttsvaevqpsvlqvvnlplverpvckastriritdnmfcagykpgegkrgdacegdsggp
fvmkspynnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvid

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1mkxL (L:)
tsedhfqpffnektfgageadcglrplfekkqvqdqtekelfesyiegr

    Sequence, based on observed residues (ATOM records): (download) 
    >1mkxL (L:)
eadcglrplfekkqvqdqtekelfesyie