PDB entry 1mhp
View 1mhp on RCSB PDB site
Description: Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody
Class: immune system
Keywords: integrin, cell adhesion, receptor, antibody, IMMUNE SYSTEM
Deposited on
2002-08-20, released
2003-04-15
The last revision prior to the SCOPe 2.04 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.222
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: integrin alpha 1, (RESIDUES 169-360)
Species: Rattus norvegicus [TaxId:10116]
Database cross-references and differences (RAF-indexed):
- Uniprot P18614 (0-191)
- engineered (72-74)
- engineered (77)
Domains in SCOPe 2.04: d1mhpa_ - Chain 'B':
Compound: integrin alpha 1, (RESIDUES 169-360)
Species: Rattus norvegicus [TaxId:10116]
Database cross-references and differences (RAF-indexed):
- Uniprot P18614 (0-191)
- engineered (72-74)
- engineered (77)
Domains in SCOPe 2.04: d1mhpb_ - Chain 'H':
Compound: Fab fragment, heavy chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d1mhph1, d1mhph2 - Chain 'L':
Compound: Fab fragment, light chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d1mhpl1, d1mhpl2 - Chain 'X':
Compound: Fab fragment, heavy chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d1mhpx_ - Chain 'Y':
Compound: Fab fragment, light chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d1mhpy_ - Heterogens: MN
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1mhpA (A:)
tqldivivldgsnsiypwesviaflndllkrmdigpkqtqvgivqygenvthefnlnkys
steevlvaankivqrggrqtmtalgidtarkeafteargarrgvkkvmvivtdgeshdny
rlkqviqdcedeniqrfsiailghynrgnlstekfveeiksiaseptekhffnvsdelal
vtivkalgerif
Sequence, based on observed residues (ATOM records): (download)
>1mhpA (A:)
tqldivivldgsnsiypwesviaflndllkrmdigpkqtqvgivqygenvthefnlnkys
steevlvaankivqrggrqtmtalgidtarkeafteargarrgvkkvmvivtdgeshdny
rlkqviqdcedeniqrfsiailgtekfveeiksiaseptekhffnvsdelalvtivkalg
erif
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1mhpB (B:)
tqldivivldgsnsiypwesviaflndllkrmdigpkqtqvgivqygenvthefnlnkys
steevlvaankivqrggrqtmtalgidtarkeafteargarrgvkkvmvivtdgeshdny
rlkqviqdcedeniqrfsiailghynrgnlstekfveeiksiaseptekhffnvsdelal
vtivkalgerif
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>1mhpH (H:)
evqlvesggglvqpggslrlscaasgftfsrytmswvrqapgkglewvatisggghtyyl
dsvkgrftisrdnskntlylqmnslraedtavyyctrgfgdggyfdvwgqgtlvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
- Chain 'L':
Sequence; same for both SEQRES and ATOM records: (download)
>1mhpL (L:)
iqltqspsslsasvgdrvtitcsasssvnhmfwyqqkpgkapkpwiyltsnlasgvpsrf
sgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveikrtvaapsvfifppsd
eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltls
kadyekhkvyacevthqglsspvtksfnrgec
- Chain 'X':
Sequence, based on SEQRES records: (download)
>1mhpX (X:)
evqlvesggglvqpggslrlscaasgftfsrytmswvrqapgkglewvatisggghtyyl
dsvkgrftisrdnskntlylqmnslraedtavyyctrgfgdggyfdvwgqgtlvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
Sequence, based on observed residues (ATOM records): (download)
>1mhpX (X:)
evqlvesggglvqpggslrlscaasgftfsrytmswvrqapgkglewvatisggghtyyl
dsvkgrftisrdnskntlylqmnslraedtavyyctrgfgdggyfdvwgqgtlvtvss
- Chain 'Y':
Sequence, based on SEQRES records: (download)
>1mhpY (Y:)
iqltqspsslsasvgdrvtitcsasssvnhmfwyqqkpgkapkpwiyltsnlasgvpsrf
sgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveikrtvaapsvfifppsd
eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltls
kadyekhkvyacevthqglsspvtksfnrgec
Sequence, based on observed residues (ATOM records): (download)
>1mhpY (Y:)
iqltqspsslsasvgdrvtitcsasssvnhmfwyqqkpgkapkpwiyltsnlasgvpsrf
sgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveik