PDB entry 1mhp

View 1mhp on RCSB PDB site
Description: Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody
Class: immune system
Keywords: integrin, cell adhesion, receptor, antibody
Deposited on 2002-08-20, released 2003-04-15
The last revision prior to the SCOP 1.75 freeze date was dated 2003-04-15, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.222
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: integrin alpha 1, (RESIDUES 169-360)
    Species: Rattus norvegicus
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18614 (0-191)
      • engineered (72-74)
      • engineered (77)
    Domains in SCOP 1.75: d1mhpa_
  • Chain 'B':
    Compound: integrin alpha 1, (RESIDUES 169-360)
    Species: Rattus norvegicus
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18614 (0-191)
      • engineered (72-74)
      • engineered (77)
    Domains in SCOP 1.75: d1mhpb_
  • Chain 'H':
    Compound: Fab fragment, heavy chain
    Species: MUS MUSCULUS
    Domains in SCOP 1.75: d1mhph1, d1mhph2
  • Chain 'L':
    Compound: Fab fragment, light chain
    Species: MUS MUSCULUS
    Domains in SCOP 1.75: d1mhpl1, d1mhpl2
  • Chain 'X':
    Compound: Fab fragment, heavy chain
    Species: MUS MUSCULUS
    Domains in SCOP 1.75: d1mhpx_
  • Chain 'Y':
    Compound: Fab fragment, light chain
    Species: MUS MUSCULUS
    Domains in SCOP 1.75: d1mhpy_
  • Heterogens: MN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1mhpA (A:)
    tqldivivldgsnsiypwesviaflndllkrmdigpkqtqvgivqygenvthefnlnkys
    steevlvaankivqrggrqtmtalgidtarkeafteargarrgvkkvmvivtdgeshdny
    rlkqviqdcedeniqrfsiailghynrgnlstekfveeiksiaseptekhffnvsdelal
    vtivkalgerif
    

    Sequence, based on observed residues (ATOM records): (download)
    >1mhpA (A:)
    tqldivivldgsnsiypwesviaflndllkrmdigpkqtqvgivqygenvthefnlnkys
    steevlvaankivqrggrqtmtalgidtarkeafteargarrgvkkvmvivtdgeshdny
    rlkqviqdcedeniqrfsiailgtekfveeiksiaseptekhffnvsdelalvtivkalg
    erif
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1mhpB (B:)
    tqldivivldgsnsiypwesviaflndllkrmdigpkqtqvgivqygenvthefnlnkys
    steevlvaankivqrggrqtmtalgidtarkeafteargarrgvkkvmvivtdgeshdny
    rlkqviqdcedeniqrfsiailghynrgnlstekfveeiksiaseptekhffnvsdelal
    vtivkalgerif
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1mhpH (H:)
    evqlvesggglvqpggslrlscaasgftfsrytmswvrqapgkglewvatisggghtyyl
    dsvkgrftisrdnskntlylqmnslraedtavyyctrgfgdggyfdvwgqgtlvtvssas
    tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
    yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1mhpL (L:)
    iqltqspsslsasvgdrvtitcsasssvnhmfwyqqkpgkapkpwiyltsnlasgvpsrf
    sgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveikrtvaapsvfifppsd
    eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltls
    kadyekhkvyacevthqglsspvtksfnrgec
    

  • Chain 'X':
    Sequence, based on SEQRES records: (download)
    >1mhpX (X:)
    evqlvesggglvqpggslrlscaasgftfsrytmswvrqapgkglewvatisggghtyyl
    dsvkgrftisrdnskntlylqmnslraedtavyyctrgfgdggyfdvwgqgtlvtvssas
    tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
    yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
    

    Sequence, based on observed residues (ATOM records): (download)
    >1mhpX (X:)
    evqlvesggglvqpggslrlscaasgftfsrytmswvrqapgkglewvatisggghtyyl
    dsvkgrftisrdnskntlylqmnslraedtavyyctrgfgdggyfdvwgqgtlvtvss
    

  • Chain 'Y':
    Sequence, based on SEQRES records: (download)
    >1mhpY (Y:)
    iqltqspsslsasvgdrvtitcsasssvnhmfwyqqkpgkapkpwiyltsnlasgvpsrf
    sgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveikrtvaapsvfifppsd
    eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltls
    kadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >1mhpY (Y:)
    iqltqspsslsasvgdrvtitcsasssvnhmfwyqqkpgkapkpwiyltsnlasgvpsrf
    sgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveik