PDB entry 1lsj

View 1lsj on RCSB PDB site
Description: Crystal Structure of the E110Q Mutant of L-3-Hydroxyacyl-CoA Dehydrogenase in Complex with NAD
Class: oxidoreductase
Keywords: Rossmann fold
Deposited on 2002-05-17, released 2004-02-03
The last revision prior to the SCOP 1.75 freeze date was dated 2004-02-03, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.21
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-hydroxyacyl-CoA dehydrogenase
    Species: HOMO SAPIENS
    Gene: HCDH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16836 (Start-301)
      • engineered (109)
    Domains in SCOP 1.75: d1lsja1, d1lsja2
  • Chain 'B':
    Compound: 3-hydroxyacyl-CoA dehydrogenase
    Species: HOMO SAPIENS
    Gene: HCDH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16836 (Start-301)
      • engineered (109)
    Domains in SCOP 1.75: d1lsjb1, d1lsjb2
  • Heterogens: NAD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1lsjA (A:)
sssstasasakkiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgiee
slrkvakkkfaenpkagdefvektlstiatstdaasvvhstdlvveaivqnlkvknelfk
rldkfaaehtifasntsslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqk
tfeslvdfskalgkhpvsckdtpgfivnrllvpylmeairlyergdaskedidtamklga
gypmgpfelldyvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfyk
yk

    Sequence, based on observed residues (ATOM records): (download) 
    >1lsjA (A:)
kiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgieeslrkvakkkfa
enpkagdefvektlstiatstdaasvvhstdlvveaivqnlkvknelfkrldkfaaehti
fasntsslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqktfeslvdfska
lgkhpvsckdtpgfivnrllvpylmeairlyergdaskedidtamklgagypmgpfelld
yvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfykyk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1lsjB (B:)
sssstasasakkiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgiee
slrkvakkkfaenpkagdefvektlstiatstdaasvvhstdlvveaivqnlkvknelfk
rldkfaaehtifasntsslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqk
tfeslvdfskalgkhpvsckdtpgfivnrllvpylmeairlyergdaskedidtamklga
gypmgpfelldyvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfyk
yk

    Sequence, based on observed residues (ATOM records): (download) 
    >1lsjB (B:)
kiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgieeslrkvakkkfa
enpkagdefvektlstiatstdaasvvhstdlvveaivqnlkvknelfkrldkfaaehti
fasntsslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqktfeslvdfska
lgkhpvsckdtpgfivnrllvpylmeairlyergdaskedidtamklgagypmgpfelld
yvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfykyk