PDB entry 1lpq

View 1lpq on RCSB PDB site
Description: Human DNA Topoisomerase I (70 Kda) In Non-Covalent Complex With A 22 Base Pair DNA Duplex Containing an 8-oxoG Lesion
Class: isomerase/DNA
Keywords: protein-DNA complex, DNA damage, induced conformational change, ISOMERASE/DNA COMPLEX
Deposited on 2002-05-08, released 2002-08-16
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 3.14 Å
R-factor: 0.256
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA topoisomerase I
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11387 (0-563)
      • engineered (521)
    Domains in SCOPe 2.01: d1lpqa1, d1lpqa2, d1lpqa3
  • Chain 'B':
    Compound: 5'-d(*ap*ap*ap*ap*ap*gp*ap*cp*tp*tp*(8og)p*gp*ap*ap*ap*ap*ap*tp*tp*tp*tp*t)-3'
  • Chain 'C':
    Compound: 5'-d(*ap*ap*ap*ap*ap*tp*tp*tp*tp*tp*cp*cp*ap*ap*gp*tp*cp*tp*tp*tp*tp*t)-3'
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1lpqA (A:)
kwkwweeerypegikwkflehkgpvfappyeplpenvkfyydgkvmklspkaeevatffa
kmldheyttkeifrknffkdwrkemtneekniitnlskcdftqmsqyfkaqtearkqmsk
eeklkikeenekllkeygfcimdnhkerianfkieppglfrgrgnhpkmgmlkrrimped
iiincskdakvpspppghkwkevrhdnkvtwlvswteniqgsikyimlnpssrikgekdw
qkyetarrlkkcvdkirnqyredwkskemkvrqravalyfidklalragnekeegetadt
vgccslrvehinlhpeldgqeyvvefdflgkdsiryynkvpvekrvfknlqlfmenkqpe
ddlfdrlntgilnkhlqdlmegltakvfrtynasitlqqqlkeltapdenipakilsynr
anravailcnhqrappktfeksmmnlqtkidakkeqladarrdlksakadakvmkdaktk
kvveskkkavqrleeqlmklevqatdreenkqialgtsklnfldpritvawckkwgvpie
kiynktqrekfawaidmadedyef

    Sequence, based on observed residues (ATOM records): (download) 
    >1lpqA (A:)
kwkwweeerypegikwkflehkgpvfappyeplpenvkfyydgkvmklspkaeevatffa
kmldheyttkeifrknffkdwrkemtneekniitnlskcdftqmsqyfkaqtearkqmsk
eeklkikeenekllkeygfcimdnhkerianfkieppglfrgrgnhpkmgmlkrrimped
iiincskdakvpspppghkwkevrhdnkvtwlvswteniqgsikyimlnpssrikgekdw
qkyetarrlkkcvdkirnqyredwkskemkvrqravalyfidklalragnekeegetadt
vgccslrvehinlhpeldgqeyvvefdflgkdsiryynkvpvekrvfknlqlfmenkqpe
ddlfdrlntgilnkhlqdlmegltakvfrtynasitlqqqlkeltapdenipakilsynr
anravailcnhqeksmmnlqtkidakkeqladarrdlksakadakvmkdaktkkvveskk
kavqrleeqlmklevqatdreenkqialgtsklnfldpritvawckkwgvpiekiynktq
rekfawaidmadedyef

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.