PDB entry 1lk6

View 1lk6 on RCSB PDB site
Description: Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an exogenous tripeptide
Class: hydrolase/hydrolase inhibitor
Keywords: Loop-sheet polymer, beta-barrel, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on 2002-04-24, released 2003-06-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.202
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: antithrombin P14-P9 peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1LK6 (0-5)
  • Chain 'D':
    Compound: exogenous tripeptide formyl-MLF
    Database cross-references and differences (RAF-indexed):
    • PDB 1LK6 (0-2)
  • Chain 'I':
    Compound: antithrombin-III
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1lk6i_
  • Chain 'L':
    Compound: antithrombin-III
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1lk6l_
  • Heterogens: NDG, NAG, GOL, HOH

PDB Chain Sequences:

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >1lk6I (I:)
    hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
    tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
    fffaklncrlyrkankssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
    qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
    kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
    pevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
    dlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfirevplnti
    ifmgrvanpcvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >1lk6I (I:)
    vdictakprdipmnpmciyrspeeatnrrvwelskansrfattfyqhladskndndnifl
    splsistafamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkankss
    klvsanrlfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnktegri
    tdvipseaineltvlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqegkf
    ryrrvaegtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldeleemmlvv
    hmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrddlyvsdafhkaflevnee
    gsastavviagrslnpnrvtfkanrpflvfirevplntiifmgrvanpcv
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >1lk6L (L:)
    hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
    tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
    fffaklncrlyrkankssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
    qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
    kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
    pevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
    dlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfirevplnti
    ifmgrvanpcvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >1lk6L (L:)
    vdictakprdipmnpmciynrrvwelskansrfattfyqhladskndndniflsplsist
    afamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkankssklvsanr
    lfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnktegritdvipse
    aineltvlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqegkfryrrvae
    gtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldeleemmlvvhmprfri
    edgfslkeqlqdmglvdlfspeksklpgivaegrddlyvsdafhkaflevneegseaaas
    tavviagrslnpnrvtfkanrpflvfirevplntiifmgrvanpcv