PDB entry 1lk3

View 1lk3 on RCSB PDB site
Description: engineered human interleukin-10 monomer complexed to 9d7 fab fragment
Class: immune system
Keywords: antigen-antibody complex, immune system
Deposited on 2002-04-23, released 2002-07-17
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.91 Å
R-factor: 0.187
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-10
    Species: Homo sapiens [TaxId:9606]
    Gene: IL10
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1lk3a_
  • Chain 'B':
    Compound: interleukin-10
    Species: Homo sapiens [TaxId:9606]
    Gene: IL10
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1lk3b_
  • Chain 'H':
    Compound: 9D7 Heavy Chain
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 1LK3 (0-218)
    Domains in SCOPe 2.03: d1lk3h1, d1lk3h2
  • Chain 'I':
    Compound: 9D7 Heavy Chain
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 1LK3 (0-218)
    Domains in SCOPe 2.03: d1lk3i1, d1lk3i2
  • Chain 'L':
    Compound: 9D7 Light Chain
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 1LK3 (0-209)
    Domains in SCOPe 2.03: d1lk3l1, d1lk3l2
  • Chain 'M':
    Compound: 9D7 Light Chain
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 1LK3 (0-209)
    Domains in SCOPe 2.03: d1lk3m1, d1lk3m2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1lk3A (A:)
msenscthfpgnlpnmlrdlrdafsrvktffqmkdqldnlllkeslledfkgylgcqals
emiqfyleevmpqaenqdpdikahvnslgenlktlrlrlrrchrflpcengggsggkska
veqvknafnklqekgiykamsefdifinyieaymtmkirn

    Sequence, based on observed residues (ATOM records): (download) 
    >1lk3A (A:)
nmlrdlrdafsrvktffqmkdqldnlllkeslledfkgylgcqalsemiqfyleevmpqa
enqdpdikahvnslgenlktlrlrlrrchrflpcekskaveqvknafnklqekgiykams
efdifinyieaymtmk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1lk3B (B:)
msenscthfpgnlpnmlrdlrdafsrvktffqmkdqldnlllkeslledfkgylgcqals
emiqfyleevmpqaenqdpdikahvnslgenlktlrlrlrrchrflpcengggsggkska
veqvknafnklqekgiykamsefdifinyieaymtmkirn

    Sequence, based on observed residues (ATOM records): (download) 
    >1lk3B (B:)
nmlrdlrdafsrvktffqmkdqldnlllkeslledfkgylgcqalsemiqfyleevmpqa
enqdpdikahvnslgenlktlrlrlrrchrflpcekskaveqvknafnklqekgiykams
efdifinyieaymtmk

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1lk3H (H:)
qvnllqsgaalvkpgasvklsckasgytftdfyihwvkqshgkslewigyinpnsgytny
nekfknkatltvdkststgymelsrltsedsanysctrgvpgnnwfpywgqgtlvtvssa
ettapsvyplapgtalksnsmvtlgclvkgyfpepvtvtwnsgalssgvhtfpavlqsgl
ytltssvtvpsstwpsqtvtcnvahpasstkvdkkivpr

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1lk3I (I:)
qvnllqsgaalvkpgasvklsckasgytftdfyihwvkqshgkslewigyinpnsgytny
nekfknkatltvdkststgymelsrltsedsanysctrgvpgnnwfpywgqgtlvtvssa
ettapsvyplapgtalksnsmvtlgclvkgyfpepvtvtwnsgalssgvhtfpavlqsgl
ytltssvtvpsstwpsqtvtcnvahpasstkvdkkivpr

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1lk3L (L:)
dtvltqppaltvspgekltisckasesvtsrmhwyqqkpgqqpklliykasnlasgvpar
fsgsgsgtdftltidpveaddtaiyfcqqswngpltfgagtklelkradaaptvsifpps
teqlatggasvvclmnnfyprdisvkwkidgterrdgvldsvtdqdskdstysmsstlsl
tkadyeshnlytcevvhktssspvvksfnr

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1lk3M (M:)
dtvltqppaltvspgekltisckasesvtsrmhwyqqkpgqqpklliykasnlasgvpar
fsgsgsgtdftltidpveaddtaiyfcqqswngpltfgagtklelkradaaptvsifpps
teqlatggasvvclmnnfyprdisvkwkidgterrdgvldsvtdqdskdstysmsstlsl
tkadyeshnlytcevvhktssspvvksfnr