PDB entry 1liy

View 1liy on RCSB PDB site
Description: Human erythrocyte pyruvate kinase: Arg479His mutant
Class: transferase
Keywords: nonspherocytic hemolytic anemia, erythrocyte, TRANSFERASE
Deposited on 2002-04-18, released 2002-09-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2007-11-20, with a file datestamp of 2007-11-16.
Experiment type: XRAY
Resolution: 2.74 Å
R-factor: 0.244
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate kinase, isozymes R/L
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered (432)
    Domains in SCOPe 2.07: d1liya4, d1liya5, d1liya6
  • Chain 'B':
    Compound: Pyruvate kinase, isozymes R/L
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered (432)
    Domains in SCOPe 2.07: d1liyb4, d1liyb5
  • Chain 'C':
    Compound: Pyruvate kinase, isozymes R/L
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered (432)
    Domains in SCOPe 2.07: d1liyc4, d1liyc5, d1liyc6
  • Chain 'D':
    Compound: Pyruvate kinase, isozymes R/L
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered (432)
    Domains in SCOPe 2.07: d1liyd4, d1liyd5, d1liyd6
  • Heterogens: FBP, PGA, K, MN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1liyA (A:)
    ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
    mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
    lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
    vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
    fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
    ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
    etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
    caaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
    ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis
    

    Sequence, based on observed residues (ATOM records): (download)
    >1liyA (A:)
    amadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniarlnfshgs
    heyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilqggpesevelvkgsqv
    lvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqeglvtqvenggvlg
    srkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavraalgpeghg
    ikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmigrcnlagkpv
    vcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpveavkmqhaiare
    aeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttghsaqllsry
    rpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgiesgklrgflr
    vgdlvivvtgwrpgsgytnimrvlsi
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1liyB (B:)
    ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
    mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
    lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
    vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
    fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
    ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
    etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
    caaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
    ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis
    

    Sequence, based on observed residues (ATOM records): (download)
    >1liyB (B:)
    qqqqlpadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniarlnf
    shgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtivelvkgsqvlvtan
    tvwvdypnivrvvpvggriyiddglislvvvenggvlgsrkgvnlpgaqdlpglseqdvr
    dlrfgvehgvdivfasfvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevs
    dgimvargdlgieipaekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsd
    vanavldgadcimlsgetakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrd
    ptevtaigaveaafkccaaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcr
    gvfpllyreppeaiwaddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrv
    lsi
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1liyC (C:)
    ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
    mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
    lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
    vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
    fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
    ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
    etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
    caaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
    ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis
    

    Sequence, based on observed residues (ATOM records): (download)
    >1liyC (C:)
    qqqlpaadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniarlnf
    shgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilqggpesevelvk
    gsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqkigpeglvtq
    venggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavra
    algpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmigr
    cnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpveavk
    mqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttgh
    saqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgies
    gklrgflrvgdlvivvtgwrpgsgytnimrvlsi
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1liyD (D:)
    ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
    mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
    lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
    vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
    fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
    ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
    etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
    caaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
    ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis
    

    Sequence, based on observed residues (ATOM records): (download)
    >1liyD (D:)
    paatflehlcllidsepvaarstsiiatigpasrsverlkemikagmniarlnfshgshe
    yhaesianvreavesfagsplsyrpvaialdtkgpeirtgilesevelvkgsqlvtvdpa
    frtrgnantvwvdypnivrvvpvggriyiddglislvvqkipelvtqvenggvlgsrkgv
    nlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavraalgpeghgikiis
    kienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmigrcnlagkpvvcatq
    mlesmitkprptraetsdvanavldgadcimlsgetakgnfpveavkmqhaiareaeaav
    yhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttghsaqllsryrpraa
    viavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgiesgklrgflrvgdlv
    ivvtgwrpgsgytnimrvlsi