PDB entry 1lix

View 1lix on RCSB PDB site
Description: Human erythrocyte pyruvate kinase: Arg486Trp mutant
Class: transferase
Keywords: nonspherocytic hemolytic anemia, erythrocyte
Deposited on 2002-04-18, released 2002-09-11
The last revision prior to the SCOP 1.73 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.87 Å
R-factor: 0.245
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate kinase, isozymes R/L
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered (439)
    Domains in SCOP 1.73: d1lixa1, d1lixa2, d1lixa3
  • Chain 'B':
    Compound: Pyruvate kinase, isozymes R/L
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered (439)
    Domains in SCOP 1.73: d1lixb1, d1lixb2, d1lixb3
  • Chain 'C':
    Compound: Pyruvate kinase, isozymes R/L
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered (439)
    Domains in SCOP 1.73: d1lixc1, d1lixc2, d1lixc3
  • Chain 'D':
    Compound: Pyruvate kinase, isozymes R/L
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered (439)
    Domains in SCOP 1.73: d1lixd1, d1lixd2, d1lixd3
  • Heterogens: FBP, PGA, K, MN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1lixA (A:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttgrsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >1lixA (A:)
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilqggpeseve
lvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqkigpegl
vtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaa
vraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmm
igrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpve
avkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltt
tgrsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfg
iesgklrgflrvgdlvivvtgwrpgsgytnimrvlsi

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1lixB (B:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttgrsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >1lixB (B:)
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgivlvtantvdy
pniviyiddglislvvvtvenggvkgvnlplpglseqdvrdlrfgvehgvdivfasfvrk
asdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvf
laqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetak
gnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaa
iivltttgrsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvd
rrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsi

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1lixC (C:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttgrsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >1lixC (C:)
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilqggpeseve
lvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqkigpegl
vtqvenggvlgsrkgvnlpgadlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavr
aalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmig
rcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpveav
kmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttg
rsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgie
sgklrgflrvgdlvivvtgwrpgsgytnimrvlsi

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1lixD (D:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttgrsaqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >1lixD (D:)
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilesevelvkg
sqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqkigpeglvtqv
enggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavraa
lgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmigrc
nlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpveavkm
qhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttgrs
aqllswyrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgiesg
klrgflrvgdlvivvtgwrpgsgytnimrvlsi