PDB entry 1le5

View 1le5 on RCSB PDB site
Description: Crystal structure of a NF-kB heterodimer bound to an IFNb-kB
Class: transcription/DNA
Keywords: PROTEIN-DNA COMPLEX, TRANSCRIPTION FACTORS, Rel/NF-kB PROTEIN, TRANSCRIPTION/DNA COMPLEX
Deposited on 2002-04-09, released 2003-04-15
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.26
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: nuclear factor nf-kappa-b p65 subunit
    Species: Mus musculus [TaxId:10090]
    Gene: rela
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04207 (2-273)
      • cloning artifact (0-1)
    Domains in SCOPe 2.06: d1le5a1, d1le5a2, d1le5a3
  • Chain 'B':
    Compound: nuclear factor nf-kappa-b p50 subunit
    Species: Mus musculus [TaxId:10090]
    Gene: NFKB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25799 (1-312)
      • initiating met (0)
    Domains in SCOPe 2.06: d1le5b1, d1le5b2
  • Chain 'C':
    Compound: 5'-d(*tp*gp*gp*gp*ap*ap*ap*tp*tp*cp*cp*t)-3'
  • Chain 'D':
    Compound: 5'-d(*ap*ap*gp*gp*ap*ap*tp*tp*tp*cp*cp*c)-3'
  • Chain 'E':
    Compound: nuclear factor nf-kappa-b p65 subunit
    Species: Mus musculus [TaxId:10090]
    Gene: rela
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04207 (2-273)
      • cloning artifact (0-1)
    Domains in SCOPe 2.06: d1le5e1, d1le5e2, d1le5e3
  • Chain 'F':
    Compound: nuclear factor nf-kappa-b p50 subunit
    Species: Mus musculus [TaxId:10090]
    Gene: NFKB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25799 (1-312)
      • initiating met (0)
    Domains in SCOPe 2.06: d1le5f1, d1le5f2
  • Chain 'G':
    Compound: 5'-d(*tp*gp*gp*gp*ap*ap*ap*tp*tp*cp*cp*t)-3'
  • Chain 'H':
    Compound: 5'-d(*ap*ap*gp*gp*ap*ap*tp*tp*tp*cp*cp*c)-3'
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1le5A (A:)
mayveiieqpkqrgmrfrykcegrsagsipgerstdttkthptikingytgpgtvrislv
tkdpphrphphelvgkdcrdgyyeadlcpdrsihsfqnlgiqcvkkrdleqaisqriqtn
nnpfhvpieeqrgdydlnavrlcfqvtvrdpagrpllltpvlshpifdnrapntaelkic
rvnrnsgsclggdeifllcdkvqkedievyftgpgweargsfsqadvhrqvaivfrtppy
adpslqapvrvsmqlrrpsdrelsepmefqylpd

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1le5B (B:)
mgpylqileqpkqrgfrfryvcegpshgglpgasseknkksypqvkicnyvgpakvivql
vtngknihlhahslvgkhcedgvctvtagpkdmvvgfanlgilhvtkkkvfetlearmte
acirgynpgllvhsdlaylqaegggdrqltdrekeiirqaavqqtkemdlsvvrlmftaf
lpdstgsftrrlepvvsdaiydskapnasnlkivrmdrtagcvtggeeiyllcdkvqkdd
iqirfyeeeenggvwegfgdfsptdvhrqfaivfktpkykdvnitkpasvfvqlrrksdl
etsepkpflyype

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1le5E (E:)
mayveiieqpkqrgmrfrykcegrsagsipgerstdttkthptikingytgpgtvrislv
tkdpphrphphelvgkdcrdgyyeadlcpdrsihsfqnlgiqcvkkrdleqaisqriqtn
nnpfhvpieeqrgdydlnavrlcfqvtvrdpagrpllltpvlshpifdnrapntaelkic
rvnrnsgsclggdeifllcdkvqkedievyftgpgweargsfsqadvhrqvaivfrtppy
adpslqapvrvsmqlrrpsdrelsepmefqylpd

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1le5F (F:)
mgpylqileqpkqrgfrfryvcegpshgglpgasseknkksypqvkicnyvgpakvivql
vtngknihlhahslvgkhcedgvctvtagpkdmvvgfanlgilhvtkkkvfetlearmte
acirgynpgllvhsdlaylqaegggdrqltdrekeiirqaavqqtkemdlsvvrlmftaf
lpdstgsftrrlepvvsdaiydskapnasnlkivrmdrtagcvtggeeiyllcdkvqkdd
iqirfyeeeenggvwegfgdfsptdvhrqfaivfktpkykdvnitkpasvfvqlrrksdl
etsepkpflyype

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.