PDB entry 1l2i

View 1l2i on RCSB PDB site
Description: Human Estrogen Receptor alpha Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a Glucocorticoid Receptor Interacting Protein 1 NR box II Peptide
Class: transcription receptor/coactivator
Keywords: nuclear receptor, transcription factor, estrogen, agonist, coactivator, TRANSCRIPTION RECEPTOR/COACTIVATOR COMPLEX
Deposited on 2002-02-21, released 2002-05-01
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.203
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • modified residue (123)
    Domains in SCOPe 2.06: d1l2ia_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • modified residue (123)
    Domains in SCOPe 2.06: d1l2ib_
  • Chain 'C':
    Compound: glucocorticoid receptor-interacting protein 1
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: glucocorticoid receptor-interacting protein 1
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CL, ETC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1l2iA (A:)
mdpmikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladre
lvhminwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrn
qgkcvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekd
hihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknv
vplydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >1l2iA (A:)
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvyleekdhihrvldkitdtlihlmaka
gltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydlllemldah

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1l2iB (B:)
mdpmikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladre
lvhminwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrn
qgkcvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekd
hihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknv
vplydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >1l2iB (B:)
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytkdhihrvldkitdtlihlmakagl
tlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydlllemldah

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.