PDB entry 1kmv

View 1kmv on RCSB PDB site
Description: human dihydrofolate reductase complexed with nadph and (z)-6-(2-[2,5-dimethoxyphenyl]ethen-1-yl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine (sri-9662), a lipophilic antifolate
Class: oxidoreductase
Keywords: oxidoreductase, antiparasitic drugs, reductase, lipophilic antifolates
Deposited on 2001-12-17, released 2002-07-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.05 Å
R-factor: 0.13
AEROSPACI score: 0.98 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: dihydrofolate reductase
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00374 (0-185)
  Domains in SCOPe 2.07: d1kmva_
• Heterogens: SO4, LII, NDP, DMS, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1kmvA (A:)
  vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
  peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
  ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
  vyeknd