PDB entry 1kms

View 1kms on RCSB PDB site
Description: human dihydrofolate reductase complexed with nadph and 6-([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine (sri-9439), a lipophilic antifolate
Class: oxidoreductase
Keywords: oxidoreductase, antiparasitic drugs, reductase, lipophilic antifolates
Deposited on 2001-12-17, released 2002-07-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.09 Å
R-factor: 0.131
AEROSPACI score: 0.94 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1kmsa_
  • Heterogens: SO4, LIH, NDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1kmsA (A:)
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

    Sequence, based on observed residues (ATOM records): (download) 
    >1kmsA (A:)
gslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsip
eknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssvy
keamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfev
yeknd