PDB entry 1kms

View 1kms on RCSB PDB site
Description: human dihydrofolate reductase complexed with nadph and 6-([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine (sri-9439), a lipophilic antifolate
Class: oxidoreductase
Keywords: oxidoreductase, antiparasitic drugs, reductase, lipophilic antifolates
Deposited on 2001-12-17, released 2002-07-10
The last revision prior to the SCOP 1.75 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.09 Å
R-factor: 0.131
AEROSPACI score: 1.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1kmsa_
  • Heterogens: SO4, LIH, NDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1kmsA (A:)
    vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
    peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
    ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
    vyeknd
    

    Sequence, based on observed residues (ATOM records): (download)
    >1kmsA (A:)
    gslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsip
    eknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssvy
    keamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfev
    yeknd